Document Detail

Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells.
MedLine Citation:
PMID:  12438159     Owner:  NLM     Status:  MEDLINE    
Serine proteases play essential roles in a wide variety of cellular processes in endocrine cells. There is a growing interest in the roles of serine protease inhibitors, or serpins, as key regulators of their activity. We have cloned two neuroserpin cDNAs from a rat pituitary cDNA library and confirmed tissue plasminogen activator as a potential target for this inhibitor. We show that neuroserpin transcripts are expressed by endocrine cells in the adrenal and pituitary glands and that immunoreactive neuroserpin is stored in densely cored secretory granules in these cells. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration.
Rena M Hill; Leigh C Coates; Parmjeet K Parmar; Eva Mezey; John F Pearson; Nigel P Birch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  971     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-19     Completed Date:  2002-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-15     Citation Subset:  IM    
Molecular Neuroendocrinology Laboratory, School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
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MeSH Terms
Adrenal Glands / cytology
Amino Acid Sequence
Cell Adhesion
Cell Communication
Cell Line
Cell Movement
Cloning, Molecular
DNA, Complementary / metabolism
Gene Library
In Situ Hybridization
Molecular Sequence Data
Neuropeptides / biosynthesis*,  chemistry,  genetics,  physiology*
Pituitary Gland / cytology*
Sequence Homology, Amino Acid
Serpins / biosynthesis*,  chemistry,  genetics,  physiology*
Reg. No./Substance:
0/DNA, Complementary; 0/Neuropeptides; 0/Serpins; 0/neuroserpin

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