| Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells. | |
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MedLine Citation:
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PMID: 12438159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serine proteases play essential roles in a wide variety of cellular processes in endocrine cells. There is a growing interest in the roles of serine protease inhibitors, or serpins, as key regulators of their activity. We have cloned two neuroserpin cDNAs from a rat pituitary cDNA library and confirmed tissue plasminogen activator as a potential target for this inhibitor. We show that neuroserpin transcripts are expressed by endocrine cells in the adrenal and pituitary glands and that immunoreactive neuroserpin is stored in densely cored secretory granules in these cells. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. |
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Authors:
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Rena M Hill; Leigh C Coates; Parmjeet K Parmar; Eva Mezey; John F Pearson; Nigel P Birch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 971 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-19 Completed Date: 2002-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 406-15 Citation Subset: IM |
Affiliation:
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Molecular Neuroendocrinology Laboratory, School of Biological Sciences, The University of Auckland, Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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cytology Amino Acid Sequence Animals Cell Adhesion Cell Communication Cell Line Cell Movement Cloning, Molecular DNA, Complementary / metabolism Gene Library In Situ Hybridization Molecular Sequence Data Neuropeptides / biosynthesis*, chemistry, genetics, physiology* Pituitary Gland / cytology* Rats Sequence Homology, Amino Acid Serpins / biosynthesis*, chemistry, genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/Neuropeptides; 0/Serpins; 0/neuroserpin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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