Document Detail


Expression and function of scalloped during Drosophila development.
MedLine Citation:
PMID:  23389965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The scalloped (sd) and vestigial (vg) genes function together in Drosophila wing development. Little is known about sd protein (SD) expression during development, or whether sd and vg interact in other developing tissues. To begin to address these questions, we generated an anti-SD antibody.
RESULTS: During embryogenesis, SD is expressed in both central and peripheral nervous systems, and the musculature. SD is also expressed in developing flight appendages. Despite SD expression herein, the peripheral nervous system, musculature, and dorsal limb primordia appeared generally normal in the absence of sd function. SD is also expressed in subsets of ventral nerve cord cells, including neuroblast 1-2 descendants and ventral unpaired median motor neurons (mVUMs). While sd function is not required to specify these neurons, it is necessary for the correct innervation of somatic muscles by the mVUMs. We also show that SD and vg protein (VG) are co-expressed in overlapping and distinctive subsets of cells in embryonic and larval tissues.
CONCLUSIONS: We describe the full breadth of SD expression during Drosophila embryogenesis, and identify a requirement for sd function in a subset of motor neurons. This work provides the necessary foundation for functional studies regarding the roles of sd during Drosophila development.
Authors:
Kirsten A Guss; Michael Benson; Nicholas Gubitosi; Karrie Brondell; Kendal Broadie; James B Skeath
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-06-03
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  242     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-01-15     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  874-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System / embryology,  metabolism
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster / embryology*,  metabolism*
Gene Expression Regulation, Developmental
Imaginal Discs / embryology,  metabolism
Muscles / embryology,  metabolism
Peripheral Nervous System / embryology,  metabolism
Transcription Factors / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
R01 MH096832/MH/NIMH NIH HHS; R01 MH096832/MH/NIMH NIH HHS; R01 NS036570/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Transcription Factors; 0/scalloped protein, Drosophila
Comments/Corrections

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