Document Detail


Expression and function of the endocannabinoid system in glial cells.
MedLine Citation:
PMID:  18781979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the last few years the role and significance of the glia in CNS function and pathology have been drastically reassessed. Glial cells physiology appears very different in healthy versus pathological brain and the recent identification of cannabinoid receptors and their endogenous ligands in glia has triggered a number of studies exploring the role of (endo)cannabinoid system in glia functionality and disease. (Endo)cannabinoids exert their effects in these cells directly affecting some important peculiar functions of the glia and actively promoting biochemical signals ending in a pro-survival fate for these cells. By contrast, (endo)cannabinoids induce a selective death in glia-derived tumor cells. Of special physiological and therapeutic relevance is the reported ability of glial cells during neuropathological conditions to release an increased amount of endocannabinoids and to overexpress cannabinoid receptors. This evidence has suggested that the endocannabinoids production by glial cells may constitute an endogenous defense mechanism preventing the propagation of neuroinflammation and cell damage. The present paper will review the evidence supporting the regulatory role of (endo)cannabinoids in glia function, holding in consideration their therapeutic potential as neuroprotective and/or anticancer agents.
Authors:
Paola Massi; Marta Valenti; Daniele Bolognini; Daniela Parolaro
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  14     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-10     Completed Date:  2008-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2289-98     Citation Subset:  IM    
Affiliation:
Department of Structural and Functional Biology, Center of Neuroscience, University of Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology
Central Nervous System Diseases / physiopathology*
Endocannabinoids / metabolism*
Gene Expression
Humans
Neuroglia / metabolism*,  physiology
Neuroprotective Agents / pharmacology
Receptors, Cannabinoid / metabolism
Signal Transduction
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Endocannabinoids; 0/Neuroprotective Agents; 0/Receptors, Cannabinoid

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