| Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. | |
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MedLine Citation:
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PMID: 6290734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution in the F344 rat liver of two extracellular matrix and basement membrane components, fibronectin and laminin, was studied by immunofluorescence. Fibronectin was found diffusely in normal liver lining the sinusoids and in connective tissue surrounding blood vessels and bile ducts; laminin was present predominantly in the basement membranes of blood vessels and bile ducts and was only inconsistently seen lining the sinusoids. After partial hepatectomy (PH), there was a transient decrease of fibronectin in the central and midzone sinusoidal hepatic areas. This decrease was most marked on day 3 after the PH. Carcinogens caused marked changes in the distribution of fibronectin. Large extracellular deposits of fibronectin were seen in areas of oval cell proliferation in livers of rats treated with N-2-fluorenylacetamide (2-FAA) while being fed a choline-deficient diet. In contrast, the nodules that developed in these livers were almost completely devoid of fibronectin staining. Neoplastic nodules produced in rats by cyclic feedings of 2-FAA r by injections of diethylnitrosamine also contained little or no fibronectin. Laminin staining did not change markedly during these treatments, but increased staining was seen associated with the newly formed ductlike structures and oval cells in liver of rats treated with carcinogens. Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell. Laminin was only found around the vascular structures within the tumors. The presence or absence of fibronectin in hepatomas did not show an obvious correlation to growth rate or metastatic potential of the tumors studied. |
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Authors:
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S Sell; E Ruoslahti |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 69 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1105-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Acetylaminofluorene Animals Carcinoma, Hepatocellular / metabolism* Diethylnitrosamine Fibronectins / analysis* Glycoproteins / analysis* Hepatectomy Laminin Liver / chemistry*, pathology Liver Neoplasms / chemically induced, metabolism*, pathology Neoplasm Proteins / analysis* Neoplasm Transplantation Neoplasms, Experimental / chemically induced, metabolism, pathology Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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CA-27460/CA/NCI NIH HHS; CA-28896/CA/NCI NIH HHS; CA-29368/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 0/Glycoproteins; 0/Laminin; 0/Neoplasm Proteins; 53-96-3/2-Acetylaminofluorene; 55-18-5/Diethylnitrosamine |
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