| Expression of fatty acid synthase (FASN) in oral nevi and melanoma. | |
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MedLine Citation:
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PMID: 21819495 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oral Diseases (2011) doi: 10.1111/j.1601-0825.2011.01841.x Objective: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. Materials and Methods: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas. Results: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression. Conclusion: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. |
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Authors:
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Bab de Andrade; Je León; R Carlos; W Delgado-Azañero; A Mosqueda-Taylor; E Graner; Op de Almeida |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-22 |
Journal Detail:
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Title: Oral diseases Volume: - ISSN: 1601-0825 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala Oral Pathology and Medicine Department, Universidad Peruana Cayetano Heredia, Peru Department of Health Care, Universidad Autónoma Metropolitana, Xochimilco, Mexico City, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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