| Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas. | |
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MedLine Citation:
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PMID: 20854471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to investigate whether the expression of ezrin, a membrane-cytoskeleton linker and regulator of cellular signaling, is associated with clinical features of chondrosarcoma. For this purpose, we studied the expression of ezrin in 54 chondrosarcomas by immunohistochemistry and correlated the expression with other tumor characteristics, markers of proliferation, apoptosis and with clinical parameters. The intensity of ezrin staining increased with the histologic grade, and a significant positive association existed between the tumor grade and ezrin expression (p = 0.0475). In addition, there was a positive correlation between the expression of ezrin and Bcl-2, an anti-apoptotic protein (r = 0.83, p < 0.0001), as well as between ezrin expression and increased proliferation as measured by Ki-67 index (r = 0.70, p < 0.0001). The positive correlation of ezrin expression with Bcl-2 and Ki-67 as well as with tumor grade suggests that an aggressive behavior of chondrosarcoma may be related to activation of ezrin and that ezrin inhibitors could provide a much needed adjuvant therapy in chondrosarcomas. In conclusion, our results indicate that high ezrin expression correlates with aggressive features of chondrosarcomas. Further analyses on the pathways downstream of ezrin are warranted. |
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Authors:
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Mirva Söderström; Tuire Palokangas; Tero Vahlberg; Tom Böhling; Hannu Aro; Olli Carpen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 118 ISSN: 1600-0463 ISO Abbreviation: APMIS Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 769-76 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal Compilation © 2010 APMIS. |
Affiliation:
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Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland. mirsod@utu.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Bone Neoplasms / immunology* Chondrosarcoma / immunology* Cytoskeletal Proteins / biosynthesis*, immunology Female Humans Immunohistochemistry Ki-67 Antigen / biosynthesis*, immunology Male Middle Aged Neoplasm Recurrence, Local / immunology Proto-Oncogene Proteins c-bcl-2 / biosynthesis*, immunology Statistics, Nonparametric Tissue Array Analysis Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytoskeletal Proteins; 0/Ki-67 Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/ezrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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