Document Detail


Expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation.
MedLine Citation:
PMID:  15165110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to investigate the changes in the expression of extracellular signal-regulated kinase (ERK1/ERK2) and angiotensin-converting enzyme (ACE) in the patients with atrial fibrillation (AF), 52 patients with rheumatic heart diseases were examined. Nineteen patients had chronic persistent AF (AF > or = 6 months, CAF), 12 patients had paroxymal AF (PAF) and 21 patients had no history of AF. The ERK expression was detected at the mRNA level by reverse transcription polymerase chain reaction, at the protein level by Western blotting and at atrial tissue level by immunohistochemistry. ERK-activating kinases (MEK1/2) and ACE were determined by Western blotting techniques. The expression of ERK2-mRNA was increased in the patients with CAF (74 +/- 19 U vs sinus rhythm: 32 +/- 24 U, P < 0.05). Activated ERK1/ERK2 and MEK1/2 were increased to more than 150% in the patients with AF compared to those with sinus rhythm. No significant difference between CAF and PAF was found. The expression of ACE was three-fold increased in the patients with CAF compared to those with sinus rhythm. Patients with AF showed an increased expression of ERK1/ERK2 in atrial interstitial cells and marked atrial fibrosis. An ACE-dependent increase in the amounts of activated ERK1/ERK2 in atrial interstitial cells may be one of molecular mechanisms for the development of atrial fibrosis in the patients with AF. These findings may have important impact on the treatment of AF.
Authors:
Youping Dai; Xiang Wang; Lingsheng Cao; Miao Yang; Tangchun Wu
Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  24     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-12-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Affiliation:
Institute of Cardiovascular Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Atrial Fibrillation / enzymology*,  etiology
Female
Gene Expression
Heart Atria / enzymology*
Humans
Male
Middle Aged
Mitogen-Activated Protein Kinase 1 / genetics,  metabolism*
Mitogen-Activated Protein Kinase 3 / genetics,  metabolism*
Peptidyl-Dipeptidase A / genetics,  metabolism*
Rheumatic Heart Disease / complications
Chemical
Reg. No./Substance:
EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 3.4.15.1/Peptidyl-Dipeptidase A
Comments/Corrections
Retraction In:
J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):234   [PMID:  18481007 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmon...
Next Document:  Effect of autonomic nervous system on the transmural dispersion of ventricular repolarization in int...