| Expression of estrogen receptor variants. | |
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MedLine Citation:
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PMID: 8007697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent data suggest that the expression of estrogen receptor (ER) variants may be common in clinical breast cancer. The significance of their expression is complicated by the fact that they are often coexpressed with wild-type ER in the same tumor. We have focused upon one such ER variant which lacks exon 5 within the hormone binding domain of the receptor. This deletion introduces a stop codon, resulting in a truncated ER of 40 kDa which is unable to bind hormone. We have been exploring the hypothesis that this variant may contribute to clinical antiestrogen resistance. Coexpression of the exon 5 variant along with wild-type ER in MCF-7 human breast cancer cells confers resistance to the commonly used antiestrogen, tamoxifen. In addition, we have observed that some metastatic breast lesions overexpress exon 5 ER deletional variant transcripts. We conclude that differences in the relative amounts of several ER variants in the same tumor may interact to determine hormonal responsiveness and metastatic behavior. |
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Authors:
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S A Fuqua; D C Allred; R J Auchus |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of cellular biochemistry. Supplement Volume: 17G ISSN: 0733-1959 ISO Abbreviation: J. Cell. Biochem. Suppl. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-07-21 Completed Date: 1994-07-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8207539 Medline TA: J Cell Biochem Suppl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 194-7 Citation Subset: IM |
Affiliation:
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University of Texas Health Science Center, Department of Medicine, San Antonio 78284. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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metabolism*,
pathology,
therapy Cell Division / drug effects Drug Resistance Exons Female Humans Mutation* Receptors, Estrogen / genetics*, metabolism Sequence Deletion Tamoxifen / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA30195/CA/NCI NIH HHS; CA52351/CA/NCI NIH HHS; CA54174/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 10540-29-1/Tamoxifen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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