| Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. | |
MedLine Citation:
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PMID: 18419678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sex hormones are known to be associated with increases of melanocytes and melanin production in human skin. However, the expression of estrogen receptor (ERalpha) in melanocytic lesions has been controversial. In 1996, a new subset of estrogen receptor was cloned, and named estrogen receptor beta (ERbeta). We used immunohistochemical staining to characterize the expression of ERalpha and ERbeta in normal skin and in melanocytic lesions. Normal sebaceous glands and hair follicles were positive for ERalpha and ERbeta. Other adnexal structures and constituents in the skin were positive for ERbeta, but not for ERalpha. Melanocytic nevi and malignant melanomas were negative for ERalpha, but both were positive for ERbeta. The ubiquitous expression of ERbeta may play a fundamental role in various normal skin cells and melanocytic tumors. |
Authors:
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Chika Ohata; Taketsugu Tadokoro; Satoshi Itami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 35 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: Japan |
Other Details:
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Languages: eng Pagination: 215-21 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Course of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. bboohay02@ybb.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Case-Control Studies Child Child, Preschool Estrogen Receptor alpha / metabolism Estrogen Receptor beta / metabolism* Female Humans Infant Male Melanoma / metabolism*, pathology Middle Aged Nevus, Pigmented / metabolism*, pathology Skin Neoplasms / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Receptor alpha; 0/Estrogen Receptor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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