Document Detail


Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas.
MedLine Citation:
PMID:  18419678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sex hormones are known to be associated with increases of melanocytes and melanin production in human skin. However, the expression of estrogen receptor (ERalpha) in melanocytic lesions has been controversial. In 1996, a new subset of estrogen receptor was cloned, and named estrogen receptor beta (ERbeta). We used immunohistochemical staining to characterize the expression of ERalpha and ERbeta in normal skin and in melanocytic lesions. Normal sebaceous glands and hair follicles were positive for ERalpha and ERbeta. Other adnexal structures and constituents in the skin were positive for ERbeta, but not for ERalpha. Melanocytic nevi and malignant melanomas were negative for ERalpha, but both were positive for ERbeta. The ubiquitous expression of ERbeta may play a fundamental role in various normal skin cells and melanocytic tumors.
Authors:
Chika Ohata; Taketsugu Tadokoro; Satoshi Itami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  35     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Course of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. bboohay02@ybb.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Child
Child, Preschool
Estrogen Receptor alpha / metabolism
Estrogen Receptor beta / metabolism*
Female
Humans
Infant
Male
Melanoma / metabolism*,  pathology
Middle Aged
Nevus, Pigmented / metabolism*,  pathology
Skin Neoplasms / metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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