Document Detail


Expression of epithelial growth factor receptor and its two ligands, transforming growth factor-alpha and epithelial growth factor, in normal and neoplastic squamous cells in the vulva: an immunohistochemical study.
MedLine Citation:
PMID:  11793194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial growth factor receptor (EGFR) sends signals to the proliferation signal transduction system, receiving two ligands: epithelial growth factor (EGF) and transforming growth factor-alpha (TGF-alpha). This immunohistochemical study examined the roles of EGFR and its ligands in the proliferation of normal and neoplastic vulvar squamous cells in 25 patients with vulvar squamous cell carcinoma (VSCC), 10 patients with vulvar condyloma acuminata (VCA), 15 patients with vulvar intra-epithelial neoplasm I-II or III (VIN I-II or III), and 5 subjects with vulvar normal squamous cells (VNSC). EGFR was detected in a few basal cells in 40% of the VNSC, in highly dysplastic cells in 40% of the VIN III, in many neoplastic cells in 80% of the VCA, and in some malignant cells in 64% of the VSCC. EGF was seen in the cytoplasm in 20% of the VIN I-II, 100% of the VIN III, 100% of the VCA, and 100% of the VSCC. Diffuse TGF-alpha was weakly expressed in the cytoplasm in 100% of the VNSC, more intensely in 100% of the VIN and 100% of the VCA, and intensely in 100% of the VSCC. These findings led to the suggestion that the TGF-alpha-EGFR system maintains the growth of normal squamous cells and, in part, maintains the growth of dysplastic and neoplastic squamous cells in the vulva. EGF expression was an early sign of neoplasia. The expression of EGFR with overexpression of its two ligands contributed to the proliferation of dysplastic and neoplastic squamous cells in VIN III and VCA. EGFR expression appeared to contribute to essential neoplastic abnormalities in 64% of the VSCC.
Authors:
X Wu; Y Xin; J Yao; K Hasui; S Tsuyama; S Yonezawa; F Murata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan     Volume:  34     ISSN:  0918-4287     ISO Abbreviation:  Med Electron Microsc     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-01-16     Completed Date:  2002-02-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9430789     Medline TA:  Med Electron Microsc     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Affiliation:
Department of Gynecology, The First Clinical College, China Medical University, Shenyang, China.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma in Situ / metabolism,  ultrastructure
Carcinoma, Squamous Cell / metabolism*,  ultrastructure
Condylomata Acuminata / metabolism,  pathology
DNA, Viral / analysis
Epidermal Growth Factor / metabolism*
Female
Humans
Immunohistochemistry
Ligands
Papillomaviridae / isolation & purification
Papillomavirus Infections / virology
Receptor, Epidermal Growth Factor / metabolism*
Transforming Growth Factor alpha / metabolism*
Tumor Virus Infections / virology
Vulva / metabolism*,  ultrastructure
Vulvar Neoplasms / metabolism*,  ultrastructure
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Ligands; 0/Transforming Growth Factor alpha; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.1/Receptor, Epidermal Growth Factor

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