Document Detail


Expression of epidermal growth factors and apoptosis markers in pancreatic ductal adenocarcinoma.
MedLine Citation:
PMID:  20430737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidermal growth factor family members: EGF, EGFR and the c-erbB-2(HER-2/neu) are involved in the growth of pancreatic ductal carcinoma, its invasiveness and metastases. Similarly, proteins regulating apoptosis can influence the development of pancreatic cancer. The aim of our study was to assess the expressions of EGF, EGFR, c-erbB-2, Bax and Bcl-xL in comparison with anatomo-clinical parameters. We also analyzed the relationship between the epidermal growth factors and apoptosis-regulating proteins. MATERIALS AND METHODS: The levels of these proteins were determined immunohistochemically in 29 pancreatic ductal carcinoma cases. RESULTS: We found no correlation of EGF, EGFR, c-erbB-2, Bax and Bcl-xL with age and gender of patients, or histological type and grade of malignancy (G). However, we observed a very strong correlation between EGF, EGFR, Bax, Bcl-xL and lymph node metastases (p=0.000, p=0.001, p=0.008, p=0.012, respectively) and between EGF, EGFR and distant metastases (p=0.002, p=0.008, respectively). Moreover, we found a correlation between Bcl-xL and c-erbB-2 (p=0.030) and between EGF and Bax (p=0.041). CONCLUSIONS: These investigations seem to suggest that both epidermal growth factors (EGF, EGFR) and apoptosis-regulating proteins (Bax and Bcl-xL) play an essential role in lymph node involvement. Moreover EGF and EGFR are involved in distant metastases. The apoptosis markers appear to cooperate with epidermal growth factor proteins in the process of tumor spread.
Authors:
Anna Pryczynicz; Katarzyna Guzińska-Ustymowicz; Jolanta Czyzewska; Andrzej Kemona
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  47     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
Affiliation:
Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apoptosis / physiology*
Carcinoma, Pancreatic Ductal* / metabolism,  pathology
Epidermal Growth Factor / metabolism*
Female
Humans
Male
Middle Aged
Pancreatic Neoplasms* / metabolism,  pathology
Proto-Oncogene Proteins c-bcl-2 / metabolism
Receptor, Epidermal Growth Factor / metabolism
Tumor Markers, Biological / metabolism*
bcl-2-Associated X Protein / metabolism
bcl-X Protein / metabolism
Chemical
Reg. No./Substance:
0/BCL2L1 protein, human; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Markers, Biological; 0/bcl-2-Associated X Protein; 0/bcl-X Protein; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.1/Receptor, Epidermal Growth Factor

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