Document Detail

Expression of epidermal growth factor in gestational trophoblastic disease (GTD).
MedLine Citation:
PMID:  9261736     Owner:  NLM     Status:  MEDLINE    
Gestational Trophoblastic Disease (GTD) is an abnormal condition of the placenta, the incidence of which is very high in the State of Kerala, India. The biology of the disease is vague and methods to determine the malignant potentialis limited. Placentae of normal (50) and molar pregnancy (95) including 32 patients showing persistent disease were used in this study. EGF expression was analyzed by immunohistochemistry using monoclonal antibody to EGF and quantitated using isotope labelled antibody to EGF. EGF was expressed more strongly in molar placentae in all gestational ages in comparison with normal placentae of similar gestational age, the expression being restricted mainly to first and second trimesters in normal placentae. Moles with early presenting symptoms (< 12 weeks) were at a higher risk for developing persistent disease. In conclusion, the immunohistochemical study shows high expression of EGF in early normal placentae and moles linking its role to proliferative and differentiating activity of trophoblasts. Tumors with histological diagnosis of invasive moles and choriocarcinoma showed very strong binding of EGF and thus EGF has the potential of identifying high risk lesions.
M John; T N Rajalekshmy; M B Nair; J Augustine; G Schultz; M K Nair; P Balaram
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  16     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Regional Cancer Centre, Trivandrum, Kerala, India.
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MeSH Terms
Choriocarcinoma / metabolism
Epidermal Growth Factor / metabolism*
Hydatidiform Mole / classification,  metabolism*
Hydatidiform Mole, Invasive / metabolism
Middle Aged
Placenta / metabolism
Reference Values
Uterine Neoplasms / classification,  metabolism*
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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