Document Detail


Expression of endothelial nitric oxide synthase traffic inducer in the placenta of pregnancy induced hypertension.
MedLine Citation:
PMID:  16961293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) in the placenta of the patients with pregnancy induced hypertension (PIH) was detected and its role in the pathogenesis of PIH was studied. The pathological changes in placental vessels were observed by HE staining. NO2-/NO3-, the stable metabolic end products of NO, was measured with nitrate reductase. The eNOS activity in placental tissues was assayed by spectrophotometry. Western blot analysis was applied to detect NOSTRIN expression. The incidence of thickening and fibronoid necrosis of placental vessels was significantly higher in women with PIH than in the normal group (P < 0.01). The levels of placental NO2-/NO3- in PIH patients (27.53 +/- 7.48 micromol/mg) were significantly lower than in normal group (54.27 +/- 9.53 micromol/mg, P < 0.01). The activity of eNOS was significantly decreased in PIH group (12.826 +/- 3.61 U/mg) as compared with that in normal group (21.72 +/- 3.83 U/mg, P < 0.01). Western blot analysis revealed that both groups expressed 58 kD NOSTRIN, but the protein level was significantly higher in women with PIH than in the normal group (P < 0.01). A significant negative correlation existed between the expression of NOSTRIN protein and the activity of eNOS in placental tissue of women with PIH (r = -0.57, P < 0.01). It was concluded that the level of NOSTRIN expression in placenta of women with PIH was increased, which may play an important role in the pathogenesis of PIH.
Authors:
Wenpei Xiang; Hanping Chen; Yuzhen Guo; Hongling Shen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  26     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-11     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  356-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blotting, Western
Endothelium, Vascular / metabolism
Female
Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Nitric Oxide Synthase Type III / metabolism*
Nitrites / metabolism
Placenta / metabolism*
Pre-Eclampsia / metabolism*
Pregnancy
Spectrophotometry
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/NOSTRIN protein, human; 0/Nitrites; EC 1.14.13.39/Nitric Oxide Synthase Type III

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