Document Detail

Expression of e-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies.
MedLine Citation:
PMID:  12496700     Owner:  NLM     Status:  MEDLINE    
E-cadherin and beta-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodelling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and beta-catenin in villous trophoblastic tissue in normal and pathological pregnancies. In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas beta-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and beta-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and beta-catenin showed a decreasing trend. In preeclampsia, there was an up-regulation of E-cadherin and beta-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta. In gestational trophoblastic diseases, there was a general trend of down-regulation of both E-cadherin and beta-catenin. Altered expression of E-cadherin and beta-catenin may play a role in the development of normal and pathological placentas.
H W Li; A N Y Cheung; S W Tsao; A L M Cheung; W S O
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  22     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-07-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Department of Anatomy, The University of Hong Kong, Pokulam, Hong Kong SAR, China.
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MeSH Terms
Cadherins / biosynthesis*
Cytoskeletal Proteins / biosynthesis*
Placenta Accreta / metabolism*,  pathology
Pre-Eclampsia / metabolism*,  pathology
Trans-Activators / biosynthesis*
Trophoblastic Neoplasms / metabolism*,  pathology
Trophoblasts / metabolism*,  pathology
Uterine Neoplasms / metabolism*,  pathology
beta Catenin
Reg. No./Substance:
0/CTNNB1 protein, human; 0/Cadherins; 0/Cytoskeletal Proteins; 0/Trans-Activators; 0/beta Catenin

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