Document Detail

Expression during rat fetal development of GLUT12--a member of the class III hexose transporter family.
MedLine Citation:
PMID:  12382147     Owner:  NLM     Status:  MEDLINE    
Glucose is an essential molecule for most mammalian cells, and is particularly important during fetal development, when cells are rapidly dividing and differentiating. In rats, GLUT1 is present at high levels in most fetal tissues, with levels decreasing after birth. We used immunohistochemistry to localise GLUT12 protein, a recently identified member of the sugar transporter family, and GLUT1 during rat fetal development. GLUT12 staining was observed in heart muscle from gestational days 15 to 21. GLUT12 staining in skeletal muscle increased from gestational days 17 to 21, and GLUT12 was also detected in brown adipose tissue. The expression of GLUT12 in insulin-responsive tissues supports a potential role for GLUT12 in the provision of glucose to these tissues before the appearance of GLUT4. GLUT12 protein was also expressed in fetal chondrocytes from gestational day 15 onward, in kidney distal tubules and collecting ducts from day 19, and in lung bronchioles from day 19. The specific pattern of expression observed in the rat fetus suggests that GLUT12 may be important in hexose delivery to developing tissues.
Maria L Macheda; Darren J Kelly; James D Best; Suzanne Rogers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-07-06
Journal Detail:
Title:  Anatomy and embryology     Volume:  205     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  441-52     Citation Subset:  IM    
Department of Medicine, St Vincent's Hospital, University of Melbourne, PO Box 2900, Fitzroy, Victoria 3065, Australia.
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MeSH Terms
Bronchi / chemistry,  embryology
Chondrocytes / chemistry
Glucose Transport Proteins, Facilitative
Glucose Transporter Type 1
Heart / embryology
Kidney Tubules, Collecting / chemistry,  embryology
Kidney Tubules, Distal / chemistry*,  embryology*
Monosaccharide Transport Proteins / analysis*
Muscle, Skeletal / chemistry,  embryology
Myocardium / chemistry*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Glucose Transport Proteins, Facilitative; 0/Glucose Transporter Type 1; 0/Monosaccharide Transport Proteins; 0/SLC2A12 protein, human; 0/Slc2a1 protein, rat
Erratum In:
Anat Embryol (Berl). 2003 Mar;206(4):335

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