Document Detail

Expression of cytokeratins in human enamel organ.
MedLine Citation:
PMID:  10706476     Owner:  NLM     Status:  MEDLINE    
Cytokeratin (CK) is a filament which plays a central role in epithelial tissue and, like the polypeptides of intermediate filaments in general, shows a high degree of tissue specificity. The CK expression patterns of odontogenic epithelia are still poorly described. We studied the distribution of individual CK polypeptides in the human enamel organ at bell stage and in remnants of the dental lamina. Our immunohistochemical study showed that epithelial cells stained for CKs 7, 13, 14 and 19 with slight changes in their pattern during the differentiation phase of odontogenesis. There was negative staining for all other CK polypeptides tested (CKs 8, 10, 16, 17 and 18). Most of the CKs in the enamel organ epithelia did not show differences related to the stage-specific state of differentiation, except for CKs 14 and 19 at the inner enamel epithelium. A strong label for CK 14 was present at the inner dental epithelium at early bell stage, and this was substituted by CK 19 at the late bell stage when the ameloblasts were fully differentiated.
M G Domingues; M M Jaeger; V C Araújo; N S Araújo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of oral sciences     Volume:  108     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  D; IM    
Department of Oral Pathology, School of Dentistry, Ibirapuera University, São Paulo, SP, Brazil.
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MeSH Terms
Ameloblasts / chemistry,  cytology
Cell Differentiation
Dental Enamel Proteins / biosynthesis*,  genetics
Enamel Organ / chemistry,  embryology,  metabolism*
Epithelium / embryology,  metabolism
Keratins / biosynthesis*,  genetics
Organ Specificity
Tooth Germ / chemistry,  embryology,  metabolism
Reg. No./Substance:
0/Dental Enamel Proteins; 68238-35-7/Keratins

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