Document Detail

Expression of cyclooxygenases in ductus arteriosus of fetal and newborn pigs.
MedLine Citation:
PMID:  9855607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We studied the ontogeny of the expression of cyclooxygenase-1 and cyclooxygenase-2 in the ductus arteriosus and evaluated their functional significance. STUDY DESIGN: The expression of cyclooxygenase-1 and cyclooxygenase-2 was studied in ductus arteriosus of fetal (at approximately 75% gestation) and term newborn pig. Effects of selective inhibitors of cyclooxygenase-1 and cyclooxygenase-2 on ductal patency were evaluated by Doppler ultrasonography. RESULTS: Ductus arteriosus of the fetus expressed virtually only cyclooxygenase-1 immunoreactive protein and activity. In contrast, the ductus of the term newborn pig (<45 minutes old) contained proteins of both cyclooxygenase-1 and cyclooxygenase-2, but the latter contributed to >90% of prostaglandin E2 formation. The selective cyclooxygenase-2 inhibitor DuP697 reduced prostaglandin E2 levels in the ductus arteriosus, albeit not in plasma, but did not affect ductal patency in the newborn pig (<1(1/2) hours old); in contrast, the cyclooxygenase-1 inhibitor valeryl salicylate, like indomethacin, markedly reduced levels of prostaglandin E2 in the plasma and ductus arteriosus and caused significant constriction of the ductus arteriosus. CONCLUSION: The ductus arteriosus of the term newborn pig, in contrast to that of the fetus, expresses cyclooxygenase-2, but circulating prostaglandins, arising mostly from cyclooxygenase-1, seem to exert the major control on ductal patency in vivo. Our data suggest that cyclooxygenase-2 inhibitors might be better alternatives for the fetus than nonselective cyclooxygenase blockers if indicated for maternal conditions such as inflammation or for tocolysis.
A M Guerguerian; P Hardy; M Bhattacharya; P Olley; R I Clyman; J C Fouron; S Chemtob
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-15     Completed Date:  1999-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1618-26     Citation Subset:  AIM; IM    
Departments of Pediatrics, Ophthalmology, and Pharmacology, University of Montreal, Canada.
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MeSH Terms
Animals, Newborn / metabolism*
Cyclooxygenase 1
Cyclooxygenase 2
Dinoprostone / biosynthesis
Ductus Arteriosus / drug effects,  enzymology*,  metabolism
Enzyme Inhibitors / pharmacology
Fetus / blood supply,  enzymology*
Isoenzymes / metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Isoenzymes; 363-24-6/Dinoprostone; EC 1; EC 2; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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