Document Detail


Expression of cyclooxygenase-2 in ovarian serous carcinoma: correlation with angiogenesis, nm23 expression and survival.
MedLine Citation:
PMID:  20099494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the expression of cyclooxygenase (COX)-2 in ovarian serous carcinomas (OSC) and its correlation with microvessel density (MVD), nm23 expression, clinicopathologic prognostic factors and survival. METHODS: Specimens from 44 patients with OSC were evaluated by immunohistochemistry for COX-2 and nm23 expression. Tumor MVD was assessed with CD34 immunostaining. The survival data of the patients were found from data files. RESULTS: 40 specimens (90.1%) showed positive COX-2 staining. Patients with high COX-2-expressed tumors had shorter overall survival, but it was not statistically significant. No correlation was found between COX-2 expression and clinicopathologic variables. There was no significant correlation between COX-2 and nm23 expression or MVD. CONCLUSIONS: COX-2 is frequently expressed in OSC. Although we could not confirm the prognostic significance of Cox-2 expression in the present cohort of OSC patients, the p value for overall survival was just slightly greater than alpha, and this result can be referred as almost significant. We considered that the limited number of cases in our study might affect the statistical analysis of our results. Further studies involving a larger number of patients are needed to clarify the prognostic significance of COX-2 expression in ovarian carcinomas.
Authors:
S Ozuysal; T Bilgin; T Ozgur; N Celik; T Evrensel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  30     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  640-5     Citation Subset:  IM    
Affiliation:
Uludag University School of Medicine, Department of Pathology, Bursa, Turkey. sema@uludag.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cyclooxygenase 2 / metabolism*
Cystadenoma, Serous / metabolism*
Female
Humans
Kaplan-Meiers Estimate
Microvessels / pathology
Middle Aged
NM23 Nucleoside Diphosphate Kinases / metabolism*
Neovascularization, Pathologic / metabolism*
Ovarian Neoplasms / metabolism*
Survival Analysis
Chemical
Reg. No./Substance:
0/NM23 Nucleoside Diphosphate Kinases; EC 1.14.99.1/Cyclooxygenase 2; EC 2.7.4.6/NME1 protein, human

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