Document Detail

Expression of connective tissue growth factor and IGF1 in normal and neoplastic gastrointestinal neuroendocrine cells and their clinico-pathological significance.
MedLine Citation:
PMID:  20959439     Owner:  NLM     Status:  MEDLINE    
Connective tissue growth factor (CTGF) and IGF1 are both expressed in a variety of tumours and are involved in tumourigenesis. However, information about their expression in the gastrointestinal (GI) neuroendocrine (NE) cells and tumours is mainly limited, with the exception of midgut carcinoids where abundant CTGF expression has been demonstrated. Normal mucosa specimens from stomach and ileum, as well as tumour tissue specimens from gastric NE tumours (GNETs; n=58) and midgut NETs (n=38) were included. Immunohistochemical techniques were used to investigate the possible expression of CTGF and IGF1 in GI NE cells and tumours. The latter results were correlated with various clinico-biochemical and histopathological variables. CTGF was expressed in a proportion of NE cells of the normal GI mucosa but not in enterochromaffin-like (ECL) cells, whereas IGF1 was undetectable. CTGF was absent in the foci of ECL cell hyperplasia, and in most of the poorly differentiated carcinomas, but present in some GNETs (mainly in type III ECL cell carcinoids (ECL-CCs)) and in all but one midgut NETs. CTGF correlated with tumour stage in well-differentiated GNETs and with size larger than 1  cm but only in the subgroup of type I ECL-CCs. IGF1 was detected in the foci of ECL cell hyperplasia and in all GI NETs. These findings suggest that both CTGF and IGF1 may be involved in the neoplastic transformation of GI NE cells, whereas IGF1 may play an important role even at early stage.
Gregory A Kaltsas; Janet L Cunningham; Sture E Falkmer; Lars Grimelius; Apostolos V Tsolakis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-13
Journal Detail:
Title:  Endocrine-related cancer     Volume:  18     ISSN:  1479-6821     ISO Abbreviation:  Endocr. Relat. Cancer     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-17     Revised Date:  2011-04-20    
Medline Journal Info:
Nlm Unique ID:  9436481     Medline TA:  Endocr Relat Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-71     Citation Subset:  IM    
Department of Pathophysiology, National University of Athens, Athens 11527, Greece.
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MeSH Terms
Adenocarcinoma / metabolism*,  pathology
Aged, 80 and over
Connective Tissue Growth Factor / biosynthesis*
Enterochromaffin-like Cells / metabolism
Gastrointestinal Neoplasms / metabolism*,  pathology
Insulin-Like Growth Factor I / biosynthesis*
Microscopy, Fluorescence
Middle Aged
Neuroendocrine Tumors / metabolism*,  pathology
Statistics, Nonparametric
Reg. No./Substance:
139568-91-5/Connective Tissue Growth Factor; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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