Document Detail


Expression of common acute lymphoblastic leukaemia antigen and terminal deoxynucleotidyl transferase in normal mononuclear blood cells during diffusion chamber culture.
MedLine Citation:
PMID:  7038845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral mononuclear blood cells of 2 healthy individuals were cultured over a 13 d period in diffusion chambers. A high percentage of cALL antigen positive cells and later on TdT containing cells appeared during culture. The cALL+ cells could be clearly distinguished into 2 groups: a population with weak and diffuse fluorescence and a small number of ring-like brightly dyed cells. The first group develops into TdT+ cells and therefore resembles immature T-cells. The interpretation of the ring-like stained cells is still preliminary, but it cannot be excluded, that these cells represent a cell population with more than lymphatic differentiation capacity.
Authors:
G Jäger; B Lau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  27     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / analysis*
Cell Differentiation
Cells, Cultured
DNA Nucleotidylexotransferase / analysis*
DNA Nucleotidyltransferases / analysis*
Fluorescent Antibody Technique
Humans
Leukemia, Lymphoid / enzymology,  immunology*
Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; EC 2.7.7.-/DNA Nucleotidyltransferases; EC 2.7.7.31/DNA Nucleotidylexotransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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