| Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck. | |
| | |
MedLine Citation:
|
PMID: 9250162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Squamous cell carcinomas (SCCs) of the head and neck are malignant tumors with high capacity to invade and metastasize. We have examined expression of the new collagenase, collagenase-3 (MMP-13), in SCCs of the head and neck. MMP-13 mRNAs were detected in 22 of 29 SCC cell lines: in 14 of 15 primary SCC cell lines and in 8 of 14 SCC cell lines from recurrent tumors or metastases. MMP-13 mRNAs were expressed by all 6 cell lines from highly invasive primary tumors and in all 4 cell lines from small aggressive tumors. Using in situ hybridization, MMP-13 mRNAs were detected in 15 of 17 SCC tumor samples. In most tumors, MMP-13 was expressed by tumor cells at the invading front of the tumors, but in a subset of SCCs, MMP-13 mRNA was also expressed by stromal fibroblasts. No MMP-13 expression was detected in intact skin or oral mucosa. MMP-13 mRNA levels in SCC cells were enhanced by transforming growth factor-beta, tumor necrosis factor-alpha, transforming growth factor-alpha, and keratinocyte growth factor. Specific expression of MMP-13 by SCC cells in vitro and in vivo strongly suggests a role for MMP-13 in the high invasion capacity of SCC cells. |
| | |
Authors:
|
N Johansson; K Airola; R Grénman; A L Kariniemi; U Saarialho-Kere; V M Kähäri |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of pathology Volume: 151 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1997 Aug |
Date Detail:
|
Created Date: 1997-08-26 Completed Date: 1997-08-26 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 499-508 Citation Subset: AIM; IM |
Affiliation:
|
Department of Dermatology, Turku University Central Hospital, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / enzymology* Collagenases / analysis, biosynthesis* Female Head and Neck Neoplasms / enzymology* Humans In Situ Hybridization Male Matrix Metalloproteinase 13 Middle Aged RNA, Messenger / analysis Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Messenger; EC 3.4.24.-/Collagenases; EC 3.4.24.-/MMP13 protein, human; EC 3.4.24.-/Matrix Metalloproteinase 13 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy-associated T-cell lym...
Next Document: Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression...