Document Detail


Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma.
MedLine Citation:
PMID:  12819390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cold-inducible RNA-binding protein (CIRP), an 18-kD protein in the mouse and human, is induced by lowering the temperature of cultured cells. CIRP is possibly a cell cycle regulator because its overexpression results in prolongation of G1 phase in vitro. We investigated the immunohistochemical expression of CIRP in 39 endometrial carcinomas, 12 endometrial hyperplasias, and 27 normal endometria using polyclonal antibody against CIRP and confirmed by Western blot analysis. CIRP was localized in the nuclei of glandular, stromal, and endothelial cells. The intensity of CIRP expression in glandular cells during the menstrual cycle was inversely proportional to its proliferative (Ki-67) activity, whereas it remained unchanged in stromal and vascular endothelial cells. The intensity of CIRP expression in hyperplastic glands was variable, whereas CIRP expression was absent or markedly reduced in most of the endometrial carcinomas. These results suggest that CIRP may participate in the cell cycle regulation of normal endometrium and the loss of its expression may be involved in endometrial carcinogenesis.
Authors:
Atia A Hamid; Masaki Mandai; Jun Fujita; Kanako Nanbu; Masatoshi Kariya; Takashi Kusakari; Ken Fukuhara; Shingo Fujii
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  22     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-7     Citation Subset:  IM    
Affiliation:
Department pf Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blotting, Western
Endometrial Hyperplasia / metabolism*
Endometrial Neoplasms / chemistry*,  pathology
Endometrium / chemistry*
Female
Humans
Immunohistochemistry
Ki-67 Antigen / analysis
Middle Aged
Neoplasm Staging
RNA-Binding Proteins / analysis*
Chemical
Reg. No./Substance:
0/CIRBP protein, human; 0/Ki-67 Antigen; 0/RNA-Binding Proteins

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