Document Detail

Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma.
MedLine Citation:
PMID:  11261824     Owner:  NLM     Status:  MEDLINE    
The type I family of growth factor receptors is known to play a role in the development of several carcinomas, but its role in hepatic malignancies is not clearly understood. In this study we investigated the expression of this family of EGF-R, c-erbB-2, c-erbB-3 and c-erbB-4 in 38 intrahepatic cholangiocellular carcinomas (CCC) by means of immunohistochemistry. EGF-R expression was related to lymph node metastasis, aberrant p53 expression, proliferating activity, and carcinoma differentiation. c-erbB-2 expression was observed in more than 50% of the cases, but was not related to any clinicopathological features, c-erbB-3 expression was linked to lymph node metastasis, and c-erbB-4 expression was directly related to proliferating activity and lymph node metastasis. These results indicate that: 1) EGF-R contributes greatly to CCC progression, and c-erbB-3 and c-erbB-4 have roles similar to but less than that of EGFR, and 2) c-erbB-2 is expressed in CCC in high incidence, but its clinical role in CCC remains unclear.
Y Ito; T Takeda; Y Sasaki; M Sakon; T Yamada; S Ishiguro; S Imaoka; M Tsujimoto; S Higashiyama; M Monden; N Matsuura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  197     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-06-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Department of Surgery, Osaka Seamen's Insurance Hospital, Japan.
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MeSH Terms
Bile Duct Neoplasms / chemistry,  metabolism*,  pathology
Bile Ducts, Intrahepatic / chemistry,  pathology*
Cholangiocarcinoma / chemistry,  metabolism*,  secondary
Ki-67 Antigen / analysis
Lymph Nodes / chemistry,  pathology
Lymphatic Metastasis / pathology
Receptor Protein-Tyrosine Kinases / analysis,  metabolism*
Reg. No./Substance:
0/Ki-67 Antigen; EC Protein-Tyrosine Kinases

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