Document Detail

Expression and clinical significance of activating transcription factor 3 in human breast cancer.
MedLine Citation:
PMID:  24494067     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer. Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent normal tissues using immunohistochemistry (IHC) assay. Categorical variables were statistically compared by chi-square or Fisher's exact test. Survival curves were evaluated using the Kaplan-Meier method and comparisons of survival rates were tested using a Log-rank test. Results : IHC analysis showed that the positive expression of ATF3 protein was detected in breast cancer tissue with a positive ratio of 76.3%, and the positive ATF3 expression in adjacent normal breast tissue was 13.2%, which is lower than that in breast cancer tissue samples (P<0.01). Furthermore, ATF3 expression showed significant correlation with TNM stage, invasion, lymph node metastasis and number of metastatic lymph nodes (P=0.038, P=0.029, P=0.026, and P=0.039 respectively), and did not correlate with patients' age and tumor size (P>0.05). A significant difference in overall survival rate was found between the patients with positive expression of ATF3 protein and those with negative expression (P=0.041). Conclusion : Increased ATF3 expression participate in the tumorigenesis, invasion and metastasis of breast cancer, and ATF3 may be useful as a new prognostic indicator for breast cancer patients.
Hua Cao; Zhi-Xue Yang; Guo-Qin Jiang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of basic medical sciences     Volume:  16     ISSN:  2008-3866     ISO Abbreviation:  Iran J Basic Med Sci     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2014-02-04     Completed Date:  2014-02-04     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101517966     Medline TA:  Iran J Basic Med Sci     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  1151-4     Citation Subset:  -    
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