Document Detail


Expression of chemerin and its receptors in rat testes and its action on testosterone secretion.
MedLine Citation:
PMID:  24301613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The novel adipokine chemerin plays a role in the regulation of lipid and carbohydrate metabolism, and recent reports of elevated chemerin levels in polycystic ovarian syndrome and preeclampsia have pointed to an emerging role of chemerin in reproduction. We hypothesised that chemerin, like other adipokines, may function to regulate male gonadal steroidogenesis. In this study, we show that chemerin and its three receptors chemokine-like receptor 1 (CMKLR1), G-protein-coupled receptor 1 (GPR1) and chemokine (C-C motif) receptor-like 2 were expressed in male reproductive tracts, liver and white adipose tissue. CMKLR1 and GPR1 proteins were localised specifically in the Leydig cells of human and rat testes by immunohistochemistry. The expression of chemerin and its receptors in rat testes was developmentally regulated and highly expressed in Leydig cells. In vitro treatment with chemerin suppressed the human chorionic gonadotropin (hCG)-induced testosterone production from primary Leydig cells, which was accompanied by the inhibition of 3β-hydroxysteroid dehydrogenase gene and protein expression. The hCG-activated p44/42 MAPK (Erk1/2) pathway in Leydig cells was also inhibited by chemerin cotreatment. Together, these data suggest that chemerin is a novel regulator of male gonadal steroidogenesis.
Authors:
Lei Li; Ping Ma; Chen Huang; Yongjun Liu; Ye Zhang; Chen Gao; Tianxia Xiao; Pei-Gen Ren; Brian A Zabel; Jian V Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-01-08
Journal Detail:
Title:  The Journal of endocrinology     Volume:  220     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-01-09     Completed Date:  2014-03-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipokines / physiology*
Animals
Cells, Cultured
Humans
Leydig Cells / metabolism
Male
Rats
Rats, Sprague-Dawley
Receptors, Chemokine / physiology*
Receptors, G-Protein-Coupled / physiology*
Testis / metabolism*
Testosterone / secretion*
Grant Support
ID/Acronym/Agency:
AI-079320/AI/NIAID NIH HHS; R01 AI079320/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adipokines; 0/Cmklr1 protein, rat; 0/Receptors, Chemokine; 0/Receptors, G-Protein-Coupled; 0/chemerin protein, rat; 3XMK78S47O/Testosterone
Comments/Corrections

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