| Expression of cellCAM-105 in the apical surface of rat uterine epithelium is controlled by ovarian steroid hormones. | |
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MedLine Citation:
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PMID: 2313638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Affinity-purified antibodies to cellCAM-105, an adhesive cell surface glycoprotein, were used in immunohistochemical investigations of rat uteri at various functional stages: (i) the oestrous, pro-oestrous, metoestrous, and dioestrous stages of the oestrous cycle, (ii) Days 1-8 of normal pregnancy, (iii) delayed implantation, (iv) 18 h after oestrogen reactivation from delay of implantation, and (v) juvenile rats, and normal ovariectomized adults, respectively, before and after experimental injection of progesterone and/or oestrogen. CellCAM-105 was present in the apical zones of the luminal and glandular epithelium cells in a stage-specific and hormone-dependent manner. The results indicate that: (1) steroid hormones are essential for the expression of cellCAM-105 in the uterine epithelial cells; (2) progesterone induces cellCAM-105 expression in the glandular epithelium, and oestrogen induces cellCAM-105 expression in the luminal epithelium; (3) progesterone induces down-regulation of cellCAM-105 from the surface of the uterine luminal epithelium of juvenile rats; (4) cellCAM-105 is absent in the luminal epithelial cells but present in the glandular epithelial cells of the rat uterus at the time of blastocyst implantation. |
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Authors:
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P C Svalander; P Odin; B O Nilsson; B Obrink |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 88 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-04-20 Completed Date: 1990-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 213-21 Citation Subset: IM |
Affiliation:
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Department of Human Anatomy, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases* Animals Antigens, CD Cell Adhesion Molecules / metabolism* Embryo Implantation, Delayed / physiology Epithelium / metabolism Estrogens / pharmacology Estrus / metabolism Female Gonadal Steroid Hormones / metabolism* Membrane Glycoproteins* Ovariectomy Pregnancy Progesterone / pharmacology Rats Rats, Inbred Strains Uterus / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD66 antigens; 0/Cell Adhesion Molecules; 0/Estrogens; 0/Gonadal Steroid Hormones; 0/Membrane Glycoproteins; 57-83-0/Progesterone; EC 3.6.1.-/Adenosine Triphosphatases |
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