| Expression of a cell surface glycoprotein (p180) related to cell-substratum adhesion during differentiation of mouse myeloid leukemia cells. | |
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MedLine Citation:
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PMID: 6253064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse myeloid leukemia M1 cells were induced to differentiate in vitro into macrophages and granulocytes by various inducers including ascitic fluid. Differentiated M1 cells induced with ascitic fluid expressed a differentiation-associated cell surface glycoprotein with a molecular weight of 180,000 (p180), which can be labeled by lactoperoxidase-catalyzed radioiodination or metabolic labeling with L-[14C]fucose. p180 was also induced by treatment with conditioned medium of hamster embryo cells, dexamethasone, dibutyryl cyclic adenosine 3':5'-monophosphate, and prostaglandin E1. Ascitic fluid, conditioned medium of hamster embryo cells, and dexamethasone induced all the differentiation-associated properties tested, whereas dibutyryl cyclic adenosine 3':5'-monophosphate and prostaglandin E1 induced lysozyme activity and adhesiveness to the substratum but not phagocytosis, locomotive activity, Fc receptors, or morphological changes. The adherent cells induced by dibutyryl cyclic adenosine 3':5'-monophosphate produced a large amount of p180, while the floating cells produced very little, but no difference was detected in the lysozyme activities of the two cell types. These results suggest that p180 is associated with cell-substratum adhesion of differentiated M1 cells. |
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Authors:
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K Sugiyama; M Tomida; Y Honma; M Hozumi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer research Volume: 40 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-01-29 Completed Date: 1981-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3387-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion* / drug effects Cell Differentiation / drug effects Cells, Cultured Cyclic AMP / pharmacology Electrophoresis, Polyacrylamide Gel Fucose / metabolism Glycoproteins / metabolism* Leukemia, Myeloid / metabolism*, ultrastructure Membrane Proteins / metabolism* Mice Muramidase / metabolism Neoplasms, Experimental / metabolism, ultrastructure Prostaglandins E / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Membrane Proteins; 0/Prostaglandins E; 3713-31-3/Fucose; 60-92-4/Cyclic AMP; EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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