| Expression of cell cycle regulator cdk2ap1 suppresses tumor cell phenotype by non-cell-autonomous mechanisms. | |
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MedLine Citation:
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PMID: 19515604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effect of expressing the cell cycle regulator cdk2ap1 in epithelial or stromal cell compartments to reduce SCC growth in vitro and in vivo. Cell-autonomous and/or non-cell-autonomous expression of cdk2ap1 reduced tumor growth and invasion and altered cell cycle, adhesion, invasion, angiogenesis, and apoptotic gene expression, as assessed by several in vitro phenotype assays, quantitative real-time PCR, and in vivo molecular imaging using a novel three-way xenograft animal model. Our findings suggest that the interactions between cancer cells and fibroblasts that promote abnormal growth can be minimized by expressing cdk2ap1, supporting a novel concept by which tumor/growth suppressor genes can impact tumorigenesis phenotypes from non-cell-autonomous interactions within the tumor microenvironment. |
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Authors:
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Olga Zolochevska; Marxa L Figueiredo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-06-09 |
Journal Detail:
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Title: Oral oncology Volume: 45 ISSN: 1368-8375 ISO Abbreviation: Oral Oncol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2011-03-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9709118 Medline TA: Oral Oncol Country: England |
Other Details:
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Languages: eng Pagination: e106-12 Citation Subset: IM |
Affiliation:
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Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, 70803, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Carcinoma, Squamous Cell / pathology* Cell Adhesion / physiology Cell Communication / physiology Cell Cycle / physiology Cell Line, Tumor Disease Models, Animal Epithelial Cells / metabolism Fibroblasts / metabolism Humans Mice Neoplasm Invasiveness / prevention & control Stromal Cells / metabolism Tumor Suppressor Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K01 CA117921-04/CA/NCI NIH HHS; K01-CA117921/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CDK2AP1 protein, human; 0/Tumor Suppressor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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