Document Detail


Expression of cell cycle inhibitor p27 and Ki-67 in human adrenocortical neoplasms.
MedLine Citation:
PMID:  9872646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent immunohistochemical analysis of cell cycle-related proteins such as p27, a cell cycle inhibitory protein, and Ki-67, a proliferation marker, indicated their possible values in predicting the biologic behavior of various human neoplasms. In this study, we performed an immunohistochemical analysis of p27 and Ki-67 in 42 adrenocortical neoplasms (12 adrenocortical carcinomas, 24 adrenocortical adenomas) and 6 normal adrenal glands to evaluate their possible values in diagnosing adrenocortical malignancy and in predicting the biologic behavior of carcinomas. We detected Ki-67 and p27 immunoreactivity in the nuclei of all of our cases, and we observed a significant negative correlation (r = -0.572, P < .001) between the p27 and Ki-67 labeling indexes (LIs). The LIs of p27 and Ki-67 were 61.7+/-2.6 and 0.28+/-0.08 in the normal adrenal cortex and 59.4+/-6.5 and 0.33+/-0.11 in the adenomas, respectively, with no significant differences between the LIs of the adenomas and normal adrenals. The LIs of p27 and Ki-67 in the carcinomas were 48.9+/-7.5 and 630+/-6.21, respectively. The LI of p27 in the carcinomas was significantly lower than that in the adenomas. The LI of Ki-67 in the carcinomas was significantly higher than that in the adenomas (P < .01). Among carcinoma cases, the Ki-67 LI in living cases tended to be lower than that in deceased cases, and the p27 LI in living cases tended to be higher than that in deceased cases, but these differences did not reach statistical significance. These results indicated that decreased p27 protein expression might cause increased cell proliferation in adrenocortical carcinoma cells in combination with other positive and/or negative regulators of the cell cycle. These results also suggested that immunohistochemical analysis of p27 and Ki-67 might be useful in distinguishing between adrenocortical adenoma and carcinoma
Authors:
H Nakazumi; H Sasano; K Iino; Y Ohashi; S Orikasa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  11     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-10     Completed Date:  1999-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-70     Citation Subset:  IM    
Affiliation:
Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / complications,  metabolism*,  pathology
Adrenal Cortex / metabolism
Adrenal Cortex Neoplasms / complications,  metabolism*,  pathology
Adult
Aged
Carcinoma / complications,  metabolism*,  pathology
Cell Count
Cushing Syndrome / etiology,  metabolism,  pathology
Diagnosis, Differential
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen / metabolism*
Male
Microfilament Proteins / metabolism*
Middle Aged
Muscle Proteins*
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; 0/Microfilament Proteins; 0/Muscle Proteins; 0/Tagln protein, mouse; 0/Tumor Markers, Biological

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