| Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts. | |
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MedLine Citation:
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PMID: 3458185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the expression of 11 cell cycle-dependent genes in senescent WI-38 fibroblasts and compared the results to those obtained in WI-38 cells from early passages (young cells). Every gene we examined is expressed in the senescent cells at levels similar to those in the young cells, including two genes maximally expressed at the G1/S phase boundary--genes for thymidine kinase and histone H3. The results clearly show that senescent, noncycling WI-38 cells are not similar to quiescent cells. Rather, such senescent WI-38 cells may be blocked just prior to the onset of DNA synthesis. |
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Authors:
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S R Rittling; K M Brooks; V J Cristofalo; R Baserga |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 83 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-06-23 Completed Date: 1986-06-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3316-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Cell Line Cell Survival* DNA Replication Gene Expression Regulation Histones / genetics Humans Interphase Proto-Oncogenes Thymidine Kinase / genetics |
| Grant Support | |
ID/Acronym/Agency:
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AG-00378/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histones; EC 2.7.1.21/Thymidine Kinase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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