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Expression of carbonic anhydrase IX in genitourinary and adrenal tumours.
MedLine Citation:
PMID:  22175902     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Donato D P, Johnson M T, Yang X J & Zynger D L (2011) Histopathology 59, 1229-1239 Expression of carbonic anhydrase IX in genitourinary and adrenal tumours Aims:  High expression of carbonic anhydrase IX (CAIX) is reported for clear cell renal cell carcinoma (RCC), with a paucity of data for non-renal genitourinary or adrenal tumours. This study investigated the immunohistochemical expression of CAIX throughout the genitourinary tract and adrenal gland. Methods and results:  High expression in the renal cortex was restricted to clear cell, papillary and clear cell papillary RCC and carcinoid. Core biopsies of clear cell RCC were consistently positive. Positivity within the urothelial tract was seen in urothelial carcinoma including squamous, small-cell, sarcomatoid and adenomatous differentiation and clear cell adenocarcinoma. Signet ring and plasmacytoid variants of urothelial carcinoma were negative. Phaeochromocytoma, adrenal cortical adenoma, seminoma, yolk sac tumour, choriocarcinoma, Leydig cell tumour and prostatic adenocarcinoma were predominately negative, with variable reactivity in adrenal cortical carcinoma, embryonal carcinoma, teratoma and Sertoli cell tumour. Conclusions:  Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available.
Authors:
Daniel P Donato; Matthew T Johnson; Ximing J Yang; Debra L Zynger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  59     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1229-39     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Limited.
Affiliation:
Departments of Pathology Urology, The Ohio State University Medical Center, Columbus, OH, USA Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
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