Document Detail


Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa.
MedLine Citation:
PMID:  3652034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of c-myb, c-myc, histone H3, and ornithine decarboxylase genes was examined by Northern blot analysis in the normal and neoplastic mucosa of ten subjects affected by colon cancer. The mRNA levels of c-myb protooncogene were detected at low levels in all normal samples but were increased in the neoplastic mucosa of six cases in comparison to the normal counterpart. In five of these six cases the mRNA levels of c-myc, histone H3, and ornithine decarboxylase mRNAs were also increased, suggesting that there is a relation between the high expression of c-myb and the fraction of cycling neoplastic cells.
Authors:
G Torelli; D Venturelli; A Coló; C Zanni; L Selleri; L Moretti; B Calabretta; U Torelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  47     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-12     Completed Date:  1987-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5266-9     Citation Subset:  IM    
Affiliation:
Center for Experimental Haematology, University of Modena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle
Colon / metabolism*
Colonic Neoplasms / metabolism*
Gene Expression Regulation*
Histones / genetics
Humans
Intestinal Mucosa / metabolism
Ornithine Decarboxylase / genetics
Proto-Oncogenes*
RNA, Messenger / analysis
Chemical
Reg. No./Substance:
0/Histones; 0/RNA, Messenger; EC 4.1.1.17/Ornithine Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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