Document Detail

Expression of c-fos, c-myb, and c-myc in human monocytes: correlation with monocytic differentiation.
MedLine Citation:
PMID:  3105625     Owner:  NLM     Status:  MEDLINE    
Terminal differentiation of human monocytic leukemia cells (THP-1 cells) was associated with the induction of c-fos, the down regulation of c-myb, and no significant change in the level of c-myc expression. Gamma interferon, which resulted in a slight decrease in c-myb but no change in c-fos or c-myc expression, had a transient antiproliferative effect without a morphological or functional differentiation of THP-1 cells. Resting human peripheral blood monocytes have a high c-fos, a low c-myc, and no detectable c-myb expression. These findings suggest that a switch in c-fos/c-myb expression is associated with the terminal differentiation of cells of the monocytic lineage.
J Lee; K Mehta; M B Blick; J U Gutterman; G Lopez-Berestein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  69     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-05     Completed Date:  1987-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1542-5     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Differentiation / drug effects*
Cell Line
Electrophoresis, Polyacrylamide Gel
Interferon-gamma / pharmacology
Macrophages / growth & development,  physiology
Monocytes / cytology*,  drug effects
Oncogenes / drug effects*
Proto-Oncogenes / drug effects*
Tetradecanoylphorbol Acetate / pharmacology
Tretinoin / pharmacology
Grant Support
5511-21//PHS HHS; 5511-23//PHS HHS
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 302-79-4/Tretinoin; 82115-62-6/Interferon-gamma; 9004-70-0/Collodion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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