Document Detail


Expression of c-fos and c-jun proteins in the marginal division of the rat striatum during learning and memory training.
MedLine Citation:
PMID:  15780209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A new brain region, the marginal division (MrD), was discovered at the caudal margin of the neostriatum. The MrD was shown to be involved in learning and memory in the rat. The aim of this study was to investigate the expression of the immediate-early genes c-fos and c-jun in the MrD of the striatum during learning and memory processes in the rat, immunocytochemical and Western blot methods were used to examine Y-maze trained rats. METHODS: The rats were divided into three groups, namely the training, pseudotraining, and control groups. After Y-maze training, the expression of the immediate-early genes c-fos and c-jun in the MrD of the rats was investigated using immunocytochemical and Western blot methods. RESULTS: After one hour of Y-maze training, the expression of c-jun and c-fos proteins was significantly enhanced in the MrD; the c-jun protein, in particular, was more intensely expressed in this region than in other parts of the striatum. The expression of these two proteins in the training group was significantly higher than in the pseudotraining and control groups. In addition, positive expression was also found in the hippocampus, cingulum cortex, thalamus, and in other areas. Western blot disclosed two immunoreactive bands for the anti-c-fos antibody (47 kD and 54 kD) and two immunoreactive bands for the anti-c-jun antibody (39 kD and 54 kD). CONCLUSIONS: These results indicate that the immediate-early genes c-fos and c-jun participate in signal transduction during the learning and memory processes associated with Y-maze training in rats.
Authors:
Xin-min Bao; Si-yun Shu; Hong Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  118     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-22     Completed Date:  2005-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  398-403     Citation Subset:  IM    
Affiliation:
Institute for Neuroscience of the First Military Medical University, Zhujiang Hospital, Guangzhou 510282, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Male
Maze Learning*
Memory*
Neostriatum / metabolism*
Proto-Oncogene Proteins c-fos / biosynthesis*
Proto-Oncogene Proteins c-jun / biosynthesis*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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