Document Detail

Expression of c-erbB-2 proto-oncogene-encoded protein (p185erbB-2) in functional rat ameloblasts.
MedLine Citation:
PMID:  7741663     Owner:  NLM     Status:  MEDLINE    
The c-erbB-2 proto-oncogene encodes a transmembrane glycoprotein with tyrosine kinase activity, p185erbB-2, that has been previously localized in some developing and mature epithelia. The possible occurrence of p185 in the inner enamel epithelium of rat tooth germ was here investigated immunocytochemically. Postmitotic functional ameloblasts displayed intense p185-immunoreactivity, thus suggesting that c-erbB-2 proto-oncogene is active during odontogenesis. The expression of this gene in differentiated and functional cells of the enamel organ suggests that its role is not restricted to mitotic events but may also be important in signalling pathways related to other cell activities.
A Casasco; M Casasco; I P Corbett; A Calligaro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  39     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  917-9     Citation Subset:  D; IM    
Institute of Histology and Embryology, University of Pavia, Italy.
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MeSH Terms
Ameloblasts / metabolism*
Dental Enamel / embryology,  metabolism
Enamel Organ / metabolism
Gene Expression
Membrane Glycoproteins / genetics,  metabolism
Mitosis / genetics
Odontogenesis / genetics
Protein-Tyrosine Kinases / genetics,  metabolism
Rats, Wistar
Receptor, erbB-2 / genetics*,  metabolism
Tooth Germ / metabolism*
Reg. No./Substance:
0/Membrane Glycoproteins; EC Kinases; EC, erbB-2

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