Document Detail

Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress.
MedLine Citation:
PMID:  2512584     Owner:  NLM     Status:  MEDLINE    
The effect of intracerebroventricular injection of the mitosis inhibitor colchicine and of immobilization stress, subcutaneous injection of capsaicin, and intraperitoneal injection of hypertonic salt solution on expression of c-Fos-like immunoreactivity was studied in the rat brain with immunohistochemistry. All the procedures induced c-Fos immunoreactivity in parvocellular neurons of the paraventricular nucleus, and many of these neurons also contained corticotropin-releasing factor immunoreactivity. c-Fos immunoreactivity was also observed, for example, in subpopulations of neurons in the locus coeruleus, the ventrolateral medulla oblongata, and the nucleus tractus solitarii. Many of these cells also expressed catecholamine-synthesizing enzymes. The results suggest that intraventricular injection of colchicine is a stressful stimulus and support the view that several catecholamine cell groups in the lower brainstem are part of the brain circuitry mediating stress reactions, as are the hypothalamic neurons that contain corticotropin-releasing factor.
S Ceccatelli; M J Villar; M Goldstein; T Hökfelt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-19     Completed Date:  1990-01-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9569-73     Citation Subset:  IM; S    
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Brain / drug effects,  metabolism*
Cell Nucleus / drug effects,  metabolism
Cerebral Ventricles / drug effects,  physiology*
Colchicine / pharmacology
Fluorescent Antibody Technique
Gene Expression
Neurons / drug effects,  enzymology*
Organ Specificity
Protein-Tyrosine Kinases / analysis
Proto-Oncogene Proteins / analysis*,  genetics
Proto-Oncogene Proteins c-fos
Rats, Inbred Strains
Reference Values
Restraint, Physical
Stress, Psychological / metabolism*
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 64-86-8/Colchicine; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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