Document Detail

Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation.
MedLine Citation:
PMID:  9344537     Owner:  NLM     Status:  MEDLINE    
In the mouse, the process of implantation is initiated by the attachment reaction between the blastocyst trophectoderm and uterine luminal epithelium that occurs at 2200-2300 h on day 4 (day 1 = vaginal plug) of pregnancy. Several members of the EGF family are considered important in embryo-uterine interactions during implantation. This investigation demonstrates that the expression of two additions to the family, betacellulin and epiregulin, are exquisitely restricted to the mouse uterine luminal epithelium and underlying stroma adjacent to the implanting blastocyst. These genes are not expressed during progesterone-maintained delayed implantation, but are rapidly switched on in the uterus surrounding the implanting blastocyst following termination of the delay by estrogen. These results provide evidence that expression of betacellulin and epiregulin in the uterus requires the presence of an active blastocyst and suggest an involvement of these growth factors in the process of implantation.
S K Das; N Das; J Wang; H Lim; B Schryver; G D Plowman; S K Dey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  190     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-24     Completed Date:  1997-11-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-90     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press.
Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160-7338, USA.
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MeSH Terms
Blotting, Northern
Embryo Implantation / genetics*
Epidermal Growth Factor / biosynthesis*
Gene Expression Regulation, Developmental
Growth Substances / biosynthesis*
In Situ Hybridization
Intercellular Signaling Peptides and Proteins*
Mice / embryology*,  genetics
Polymerase Chain Reaction
RNA, Messenger / analysis
Time Factors
Tissue Distribution
Uterus / metabolism*
Grant Support
Reg. No./Substance:
0/Growth Substances; 0/Intercellular Signaling Peptides and Proteins; 0/RNA, Messenger; 0/betacellulin; 0/epiregulin; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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