| Expression of basal cell marker revealed by RAM11 antibody during epithelial regeneration in rabbits. | |
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MedLine Citation:
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PMID: 20529822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RAM11 is a mouse monoclonal anti-rabbit macrophage antibody recognizing connective tissue and vascular macrophages. Our previous report showed that RAM11 reacted with basal cells of stratified squamous epithelia of rabbit skin, oral mucosa and esophagus. The aim of the present study was to follow the appearance of RAM11 immunoreactivity in basal cells of regenerating oral epithelium in rabbits. No RAM11 immunostaining was observed in the regenerating epithelium examined on days 1 and 3 of wound healing. A weak immunofluorescence first appeared on day 7 in single basal cells and 32% of RAM11- positive basal cells were observed on day 14. These findings indicate that expression of the antigen recognized by RAM11 antibody is a transient event in the differentiation of oral keratinocytes which not always occurs during epithelial repair, although it is a constant feature of epithelial turnover in mature epithelium. Therefore this antigen can be regarded as basal cell marker only in mature stratified squamous epithelia. |
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Authors:
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Grzegorz J Lis; Ewa Jasek; Jan A Litwin; Mariusz Gajda; Joanna Zarzecka; Tadeusz Cichocki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society Volume: 48 ISSN: 1897-5631 ISO Abbreviation: Folia Histochem. Cytobiol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502651 Medline TA: Folia Histochem Cytobiol Country: Poland |
Other Details:
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Languages: eng Pagination: 89-92 Citation Subset: IM |
Affiliation:
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Department of Histology, Institute of Stomatology, Jagiellonian University Medical College, Kraków, Poland. mmlis@cyf-kr.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / immunology* Biological Markers / metabolism Epithelial Cells / cytology, metabolism Epithelium / physiology* Microscopy, Fluorescence Rabbits Regeneration / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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