Document Detail


Expression of apoptotic and cell proliferation regulatory proteins in keratoacanthomas and squamous cell carcinomas of the skin.
MedLine Citation:
PMID:  18079070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the expression of p53, caspase-3, bcl-2, MIB-1, and PCNA to validate more objective methods to differentiate squamous cell carcinoma and keratoacanthoma, as well as to understand their pathogenesis with accuracy. A total of 52 cases of histopathologically diagnosed keratoacanthoma in the proliferative stage and 56 cases of well-differentiated squamous cell carcinoma were selected in this study. The expression was evaluated by means of immunohistochemistry. Bcl-2 immunoreactivity was weak or absent in the majority of cases, either in squamous cell carcinoma or in keratoacanthoma. PCNA-positive cells did not show differences between two lesions evaluated. On the other hand, MIB-1 was statistically significant (p<0.05) between squamous cell carcinomas and keratoacanthomas. Moreover, p53 and caspase-3 were overexpressed in squamous cell carcinomas. Together, these results suggest that the biological behavior of the well-differentiated squamous cell carcinomas of the skin may be associated with cellular proliferation and/or deregulation of cell death, indicated by increased expression of the MIB-1 and apoptotic proteins p53 and caspase-3, respectively.
Authors:
Daniel Ribeiro; Silvia Narikawa; Mariângela E A Marques
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology, research and practice     Volume:  204     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Affiliation:
Department of Health Sciences, Federal University of Sao Paulo, UNIFESP, Santos, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Apoptosis Regulatory Proteins / analysis*
Carcinoma, Squamous Cell / chemistry*,  enzymology,  immunology,  pathology
Caspase 3 / analysis
Cell Cycle Proteins / analysis*
Cell Differentiation
Cell Proliferation*
Diagnosis, Differential
Humans
Immunohistochemistry
Keratoacanthoma / enzymology,  immunology,  metabolism*,  pathology
Ki-67 Antigen / analysis
Proliferating Cell Nuclear Antigen / analysis
Proto-Oncogene Proteins c-bcl-2 / analysis
Skin Neoplasms / chemistry*,  enzymology,  immunology,  pathology
Tumor Suppressor Protein p53 / analysis
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Cell Cycle Proteins; 0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen; 0/Proto-Oncogene Proteins c-bcl-2; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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