| Expression of apoptosis-inducing factor (AIF) in keratoacanthomas and squamous cell carcinomas of the skin. | |
| | |
MedLine Citation:
|
PMID: 21410769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The complex biological trait 'susceptibility to apoptosis' is a nosological feature distinguishing squamous cell carcinomas (SCC) from keratoacanthomas (KA). The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens. SCC express statistically significant more AIF than KA both as proportion of AIF+ cells by immunohistochemistry (median: 54% vs 33%; P < 0.01) and as total AIF protein content by western blot quantification (six-fold increased; P < 0.01). However, the contribution of AIF to apoptosis, measured as fraction of apoptotic nuclei with overt DNA fragmentation by the TUNEL method that co-express AIF translocated to nucleus, is significantly less prevalent among SCC (median: 19% vs 48% in KA; P < 0.01). These findings indicate to a distinctive involvement of AIF in the progression of certain epithelial skin tumors that might be exploited as a promising treatment target. |
| | |
Authors:
|
Angelos Skyrlas; Markus Hantschke; V Passa; Georgios Gaitanis; Vasiliki Malamou-Mitsi; Ioannis D Bassukas |
Related Documents
:
|
15778979 - Endogenously expressed estrogen receptors mediate neuroprotection in hippocampal cells ... 21048809 - Anti-stress action of several orally-given β-glucans. 9880239 - Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control ... 16877119 - Social interactions, stress, and immunity. 21034299 - Chronic stress and environmental enrichment as opposite factors affecting the immune re... 19883139 - Stress and specificity: reply to miller (2009). 21685479 - Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory r... 18827909 - The secretory phospholipase a2 group iia: a missing link between inflammation, activate... 21239719 - Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in exper... |
Publication Detail:
|
Type: LETTER Date: 2011-3-16 |
Journal Detail:
|
Title: Experimental dermatology Volume: - ISSN: 1600-0625 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Department of Pathology, University of Ioannina Medical School, Ioannina, Greece Dermatopathologie Friedrichshafen, Friedrichshafen, Germany Department of Skin and Venereal Diseases, University of Ioannina Medical School, Ioannina, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibitory effects of 16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid B) isol...
Next Document: Persistent CMV infection correlates with disease activity and dominates the phenotype of peripheral ...