Document Detail


Expression of antioxidant enzymes in astrocytic brain tumors.
MedLine Citation:
PMID:  12744469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the expression of antioxidant enzymes (AOEs) and related proteins manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR), and the catalytic (GLCL-c) and regulatory (GLCL-r) subunits of glutamate cysteine ligase (gamma-glutamylcysteinesynthetase) in 433 astrocytomas. Expression of MnSOD was found in 91%, Trx in 46%, TrxR in 66%, GLCL-c 73% and GLCL-r in 89% of the cases. Diffuse astrocytomas showed more intense staining for Trx (p = 0.002), TrxR (p = 0.004), GLCL-c (p = 0.001), GLCL-r (p = 0.04) and MnSOD (p = 0.01) than pilocytic astrocytomas. Within diffuse astrocytomas only Trx (p = 0.0001) and TrxR (p= 0.04) significantly associated with increased malignancy grade. Necrotic tumors were more often immunopositive for Trx (p = 0.001) and TrxR (p = 0.02) and AOE expression was generally higher in mitotically active tumors. Expression of Trx and lack of MnSOD expression was associated with a worse prognosis in diffuse astrocytomas. None of the AOEs had any prognostic value in pilocytic grade I astrocytomas. Familial astrocytomas, which included 23 of the cases studied, did not differ in their expression of MnSOD from sporadic ones. The results show that MnSOD and Trx may influence the biological behaviour of astrocytomas, possibly by modulating cell proliferation and necrosis in these tumors.
Authors:
Hannu Haapasalo; Maarit Kyläniemi; Niina Paunul; Vuokko L Kinnula; Ylermi Soini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  13     ISSN:  1015-6305     ISO Abbreviation:  Brain Pathol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-14     Completed Date:  2003-06-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  155-64     Citation Subset:  IM    
Affiliation:
Department of Pathology, Tampere University Hospital, Tampere, Finland.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism
Astrocytoma / enzymology*,  genetics,  mortality
Brain Neoplasms / diagnosis,  enzymology,  genetics
Cell Transformation, Neoplastic / genetics
Free Radical Scavengers / metabolism
Gene Expression Profiling
Glioblastoma / enzymology*,  genetics,  mortality
Glutamate-Cysteine Ligase / genetics
Humans
Immunohistochemistry
Oligonucleotide Array Sequence Analysis
Oxidoreductases / metabolism*
Prognosis
Superoxide Dismutase / genetics
Survival Analysis
Thioredoxin-Disulfide Reductase / genetics
Thioredoxins / genetics
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 52500-60-4/Thioredoxins; EC 1.-/Oxidoreductases; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.9/Thioredoxin-Disulfide Reductase; EC 6.3.2.2/Glutamate-Cysteine Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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