| Expression of antioxidant enzymes in astrocytic brain tumors. | |
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MedLine Citation:
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PMID: 12744469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the expression of antioxidant enzymes (AOEs) and related proteins manganese superoxide dismutase (MnSOD), thioredoxin (Trx), thioredoxin reductase (TrxR), and the catalytic (GLCL-c) and regulatory (GLCL-r) subunits of glutamate cysteine ligase (gamma-glutamylcysteinesynthetase) in 433 astrocytomas. Expression of MnSOD was found in 91%, Trx in 46%, TrxR in 66%, GLCL-c 73% and GLCL-r in 89% of the cases. Diffuse astrocytomas showed more intense staining for Trx (p = 0.002), TrxR (p = 0.004), GLCL-c (p = 0.001), GLCL-r (p = 0.04) and MnSOD (p = 0.01) than pilocytic astrocytomas. Within diffuse astrocytomas only Trx (p = 0.0001) and TrxR (p= 0.04) significantly associated with increased malignancy grade. Necrotic tumors were more often immunopositive for Trx (p = 0.001) and TrxR (p = 0.02) and AOE expression was generally higher in mitotically active tumors. Expression of Trx and lack of MnSOD expression was associated with a worse prognosis in diffuse astrocytomas. None of the AOEs had any prognostic value in pilocytic grade I astrocytomas. Familial astrocytomas, which included 23 of the cases studied, did not differ in their expression of MnSOD from sporadic ones. The results show that MnSOD and Trx may influence the biological behaviour of astrocytomas, possibly by modulating cell proliferation and necrosis in these tumors. |
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Authors:
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Hannu Haapasalo; Maarit Kyläniemi; Niina Paunul; Vuokko L Kinnula; Ylermi Soini |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain pathology (Zurich, Switzerland) Volume: 13 ISSN: 1015-6305 ISO Abbreviation: Brain Pathol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-14 Completed Date: 2003-06-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216781 Medline TA: Brain Pathol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 155-64 Citation Subset: IM |
Affiliation:
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Department of Pathology, Tampere University Hospital, Tampere, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism Astrocytoma / enzymology*, genetics, mortality Brain Neoplasms / diagnosis, enzymology, genetics Cell Transformation, Neoplastic / genetics Free Radical Scavengers / metabolism Gene Expression Profiling Glioblastoma / enzymology*, genetics, mortality Glutamate-Cysteine Ligase / genetics Humans Immunohistochemistry Oligonucleotide Array Sequence Analysis Oxidoreductases / metabolism* Prognosis Superoxide Dismutase / genetics Survival Analysis Thioredoxin-Disulfide Reductase / genetics Thioredoxins / genetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 52500-60-4/Thioredoxins; EC 1.-/Oxidoreductases; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.9/Thioredoxin-Disulfide Reductase; EC 6.3.2.2/Glutamate-Cysteine Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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