| Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury. | |
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MedLine Citation:
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PMID: 17112829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have recently shown that experimental traumatic brain injury (TBI) results in ultrastructural damage in heart tissue. The aim of this study was to determine the two antiapoptotic signals "survivin" and "aven" in rat heart tissue following TBI, and comparing the effects of erythropoietin (EPO) and methylprednisolone (MPS). Thirty-six Wistar-Albino female rats weighing 190 to 230 g were randomly allocated into six groups: group 1 underwent head trauma with no treatment; group 2 and group 3, head trauma and intraperitoneally delivered EPO (1000 IU/kg) and MPS (30 mg/kg), respectively; group 4 (vehicle), head trauma and intraperitoneal albumin (0.4 mL/rat); groups 5 and 6, control and sham-operated groups, respectively. Three-hundred g-cm impact trauma was produced by the method of weight-drop. Real-time quantitative polymerase chain reactions were used to estimate survivin and aven gene expression at the total RNA level. Both survivin and aven were higher among the treatment than the trauma group (P = .0006, .0001 and P = .0038, .0033, respectively). Comparing survivin and aven between EPO and MPS treatment groups showed no significance (P = .3027, .2171, respectively). Also, both survivin and aven were significantly higher among the treatment than the vehicle, the control, or the sham-operated groups. These findings suggested that both EPO and MPS may play important roles in the expression of antiapoptotic survivin and aven genes in heart tissue after TBI. |
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Authors:
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K Ozisik; P Ozisik; E Yildirim; M Misirlioglu; S Tuncer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-02-12 Revised Date: 2010-08-31 |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2784-7 Citation Subset: IM |
Affiliation:
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Ankara Numune Education and Research Hospital, Ankara, Turkey. sozisik2002@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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genetics* Animals Apoptosis Regulatory Proteins / genetics* Brain Injuries / drug therapy, physiopathology* DNA Primers DNA, Complementary / genetics, isolation & purification Erythropoietin / therapeutic use Gene Expression Regulation* Heart / physiopathology* Methylprednisolone / therapeutic use Microtubule-Associated Proteins / genetics* Muscle Cells / drug effects, physiology Polymerase Chain Reaction RNA / genetics, isolation & purification Rats |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Apoptosis Regulatory Proteins; 0/Birc5 protein, rat; 0/DNA Primers; 0/DNA, Complementary; 0/Microtubule-Associated Proteins; 0/aven protein, rat; 11096-26-7/Erythropoietin; 63231-63-0/RNA; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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