| Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension. | |
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MedLine Citation:
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PMID: 20802542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p<0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p<0.05), while the placental expression of procathepsin D was significantly greater in PIH cases than in the normal pregnancies (p<0.05). These data suggest that antiangiogenic PRL fragments in the placenta may be present only in PIH cases, and that PRL fragments in the placenta might be implicated in the pathophysiology of PIH. |
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Authors:
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Akio Masumoto; Hisashi Masuyama; Norio Takamoto; Yoichiro Akahori; Yuji Hiramatsu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica Okayama Volume: 64 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: Japan |
Other Details:
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Languages: eng Pagination: 249-55 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hiroshima City Hospital, Hiroshima 730-8518, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cathepsin D / metabolism Enzyme Precursors / metabolism Female Humans Hypertension, Pregnancy-Induced / metabolism*, physiopathology Peptide Fragments / metabolism* Placenta / metabolism* Pregnancy Prolactin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; 0/Peptide Fragments; 9002-62-4/Prolactin; EC 3.4.23.-/procathepsin D; EC 3.4.23.5/Cathepsin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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