| Expression of annexin A1 mRNA in peripheral blood from oral squamous cell carcinoma patients. | |
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MedLine Citation:
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PMID: 19833546 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Several studies have been suggesting annexin A1 protein as an active player in tumorigenesis of many organs. Nevertheless, its tumor biomarker role has been mainly studied in tissues by immunohistochemistry or cell culture. Hence, in this investigation, the peripheral blood from 27 oral squamous cell carcinoma (OSCC) patients and 25 negative control individuals were examined by quantitative real-time PCR. Down-regulated ANXA1 expression at mRNA level was observed in OSCC samples (p=0.026). Significantly diminished mRNA levels correlated to age, sex and the anatomical site of the tumor lesion were observed. Moreover, the ROC curve analysis revealed the performance of ANXA1 expression as a suitable biomarker for patients with oral cavity cancer, especially those with 60years of age or older and/or women. For the first time, ANXA1 mRNA is revealed as blood-based biomarker, and its adoption for complementary non-invasive diagnosis of OSCC is suggested. These results suggest that, beyond the anti-inflammatory function, annexin A1 may also play a tumor suppressor role in peripheral blood cells, such as leukocytes. |
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Authors:
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Paula Cristina Batista Faria; Angela Aparecida Servino Sena; Rafael Nascimento; Washington João Carvalho; Adriano Mota Loyola; Sindeval José Silva; Antônio Francisco Junior Durighetto; Anísio Domingos Junior Oliveira; Sonia Maria Oliani; Luiz Ricardo Goulart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-14 |
Journal Detail:
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Title: Oral oncology Volume: 46 ISSN: 1368-8375 ISO Abbreviation: Oral Oncol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709118 Medline TA: Oral Oncol Country: England |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Affiliation:
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Federal University of Uberlândia, Av. Amazonas, 902 Uberlândia, MG, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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