| Expression of angiotensin converting enzyme mRNA in rat brain. | |
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MedLine Citation:
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PMID: 1662749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using molecular genetic approaches, two forms of angiotensin-converting enzyme (ACE) have so far been identified; a pulmonary form and a testicular form. This study utilized both northern blot analysis and in-situ hybridization to examine the expression of ACE mRNA in the rat brain. Northern blot analysis using oligonucleotide probes specific to the testicular or pulmonary forms of ACE demonstrated expression of a 4-5kb mRNA doublet in the rat brain, identical in size to pulmonary ACE mRNA. No expression of the testicular form of ACE mRNA was detected in the brain. In situ hybridization demonstrated that ACE mRNA was expressed in the choroid plexus, caudate putamen and cerebellum. A weak signal was also observed in the hippocampus. This distribution correlated well with the expression of ACE mapped by radioligand binding and autoradiography. |
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Authors:
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P Whiting; S Nava; L Mozley; H Eastham; J Poat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research. Molecular brain research Volume: 11 ISSN: 0169-328X ISO Abbreviation: Brain Res. Mol. Brain Res. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1992-02-14 Completed Date: 1992-02-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8908640 Medline TA: Brain Res Mol Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
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Merck Sharp and Dohme Research Laboratory, Neuroscience Research Centre, Harlow, Essex, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Blotting, Northern Brain / metabolism* Male Molecular Sequence Data Nucleic Acid Hybridization Oligonucleotide Probes Peptidyl-Dipeptidase A / genetics* RNA, Messenger / biosynthesis*, genetics Rats Rats, Inbred Strains Sequence Homology, Nucleic Acid |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotide Probes; 0/RNA, Messenger; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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