Document Detail

Expression of angiotensin converting enzyme mRNA in rat brain.
MedLine Citation:
PMID:  1662749     Owner:  NLM     Status:  MEDLINE    
Using molecular genetic approaches, two forms of angiotensin-converting enzyme (ACE) have so far been identified; a pulmonary form and a testicular form. This study utilized both northern blot analysis and in-situ hybridization to examine the expression of ACE mRNA in the rat brain. Northern blot analysis using oligonucleotide probes specific to the testicular or pulmonary forms of ACE demonstrated expression of a 4-5kb mRNA doublet in the rat brain, identical in size to pulmonary ACE mRNA. No expression of the testicular form of ACE mRNA was detected in the brain. In situ hybridization demonstrated that ACE mRNA was expressed in the choroid plexus, caudate putamen and cerebellum. A weak signal was also observed in the hippocampus. This distribution correlated well with the expression of ACE mapped by radioligand binding and autoradiography.
P Whiting; S Nava; L Mozley; H Eastham; J Poat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  11     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Merck Sharp and Dohme Research Laboratory, Neuroscience Research Centre, Harlow, Essex, U.K.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Blotting, Northern
Brain / metabolism*
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
Peptidyl-Dipeptidase A / genetics*
RNA, Messenger / biosynthesis*,  genetics
Rats, Inbred Strains
Sequence Homology, Nucleic Acid
Reg. No./Substance:
0/Oligonucleotide Probes; 0/RNA, Messenger; EC A

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