Document Detail


Expression of angiotensin converting enzyme mRNA in rat brain.
MedLine Citation:
PMID:  1662749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using molecular genetic approaches, two forms of angiotensin-converting enzyme (ACE) have so far been identified; a pulmonary form and a testicular form. This study utilized both northern blot analysis and in-situ hybridization to examine the expression of ACE mRNA in the rat brain. Northern blot analysis using oligonucleotide probes specific to the testicular or pulmonary forms of ACE demonstrated expression of a 4-5kb mRNA doublet in the rat brain, identical in size to pulmonary ACE mRNA. No expression of the testicular form of ACE mRNA was detected in the brain. In situ hybridization demonstrated that ACE mRNA was expressed in the choroid plexus, caudate putamen and cerebellum. A weak signal was also observed in the hippocampus. This distribution correlated well with the expression of ACE mapped by radioligand binding and autoradiography.
Authors:
P Whiting; S Nava; L Mozley; H Eastham; J Poat
Related Documents :
23554459 - Microrna-638 is highly expressed in human vascular smooth muscle cells and inhibits pdg...
23315269 - Micrornas in the brain: it's regulatory role in neuroinflammation.
24424209 - The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cel...
24485069 - Immunohistochemical expression of mmp-14 and mmp-2, and mmp-2 activity during human ova...
9730699 - Tissue-specific expression of human angiotensin ii at1 and at2 receptors and cellular l...
24391759 - Uva and uvb irradiation differentially regulate microrna expression in human primary ke...
12769839 - Early formation of mrnp: license for export or quality control?
23302779 - Inflammation induced by raw macrophages suppresses ucp1 mrna induction via erk activati...
11893339 - Expression of constitutively active creb protein facilitates the late phase of long-ter...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  11     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Affiliation:
Merck Sharp and Dohme Research Laboratory, Neuroscience Research Centre, Harlow, Essex, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Brain / metabolism*
Male
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
Peptidyl-Dipeptidase A / genetics*
RNA, Messenger / biosynthesis*,  genetics
Rats
Rats, Inbred Strains
Sequence Homology, Nucleic Acid
Chemical
Reg. No./Substance:
0/Oligonucleotide Probes; 0/RNA, Messenger; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A negative correlation between the induction of long-term potentiation and activation of immediate e...
Next Document:  Nerve regeneration through a two-ply biodegradable nerve guide in the rat and the influence of ACTH4...