Document Detail

Expression of angiogenesis-stimulating factors (VEGF, CD31, CD105) and angiogenetic index in gingivae of patients with chronic periodontitis.
MedLine Citation:
PMID:  23264219     Owner:  NLM     Status:  In-Data-Review    
The aim of this study was to determine the prognostic value of the angiogenesis rate in chronic periodontitis(CP). A total of 61 human gingival samples were taken from patients with CP (n = 40) obtained duringopen curettage with gingivectomy, healthy periodontia (n = 15), and reactive lymph nodes (n = 7). Quantitativeimmunocytochemistry studies of VEGF, CD31 (PECAM-1) and CD105 (endoglin) were performed using thespatial visualization method. CD105/CD31 and VEGF/CD31 angiogenetic ratios (ARs) were established todetermine the proliferation fraction of the endothelium. In patients with CP, the proliferation of blood vesselswas observed, including the presence of numerous high endothelial venules (HEVs) and ordinary vessels. Ingingival HEVs of patients with CP, the higher expression was shown by CD31 and, in turn CD105 and VEGF.The entire vascular expression of CD31 in the gingiva correlates with grading in lamina propria, but our studyfailed to document correlations between the expression of VEGF and CD105 and clinical data of patients withCP. Higher ARs were seen in gingivae of CP patients compared to controls. We concluded that overexpressionof the angiogenesis-associated factors in CP suggests its significance in protracting the inflammatory process orperiodic exacerbations of the process and destruction of the periodontium. The increased CD105/CD31 andVEGF/CD31 ratios in gingiva confirms an augmented proliferative fraction of the endothelium in gingiva withCP.
Aldona Kasprzak; Anna Surdacka; Maciej Tomczak; Wieslawa Przybyszewska; Agnieszka Seraszek-Jaros; Agata Malkowska-Lanzafame; Elzbieta Siodla; Elzbieta Kaczmarek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  50     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  554-64     Citation Subset:  IM    
Chair and Department of Histology and Embryology, Poznan University of Medical Sciences in Poznan, Poland.
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