| Expression of androgen receptor in human placentas from normal and preeclamptic pregnancies. | |
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MedLine Citation:
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PMID: 19797017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To elucidate the expression of androgen receptor (AR) in human placenta from normal and preeclamptic (PE) pregnancies. MATERIALS AND METHODS: This study was performed at the Division of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Academic Medical Center. Forty normal pregnant women at 37.0 +/- 0.89 weeks' gestation and 40 women with preeclampsia at 35.9 +/- 1.33 weeks' gestation were included in this study. Serum testosterone was measured before delivery. Immunochemical methodology was employed in formalin-fixed, paraffin-embedded sections from the placentas of all subjects. AR expression was evaluated in placentas collected from 15 normal pregnant women and 12 PE women. RESULTS: Women with preeclampsia had an elevated serum testosterone level (0.52 +/- 0.13 vs. 0.34 +/- 0.11 ng/mL; p < 0.01). The expression of AR in both placentas was confirmed using immunohistochemistry and was primarily present in the nucleus and cytoplasm of syncytiotrophoblasts and stromal cells. There was a significant increase in AR mRNA expression in PE placentas compared with normal placentas. CONCLUSION: These data suggest that the increased AR expression may alter AR-mediated function on syncytiotrophoblasts and stromal cells in PE placentas, and be a possible mechanism for its association with preeclampsia. |
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Authors:
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Te-Yao Hsu; Kuo-Chung Lan; Chih-Chang Tsai; Chi-Yu Ou; Bi-Hua Cheng; Men-Yin Tsai; Hong-Yo Kang; Yu-Hsia Tung; Yi-Hush Wong; Ko-En Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Taiwanese journal of obstetrics & gynecology Volume: 48 ISSN: 1875-6263 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2009-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213819 Medline TA: Taiwan J Obstet Gynecol Country: China |
Other Details:
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Languages: eng Pagination: 262-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fixatives Formaldehyde Gene Expression / physiology Gestational Age Humans Immunohistochemistry Paraffin Embedding Placenta / pathology, physiology* Pre-Eclampsia / pathology, physiopathology* Pregnancy RNA, Messenger / metabolism Receptors, Androgen / genetics*, metabolism* Reverse Transcriptase Polymerase Chain Reaction Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Fixatives; 0/RNA, Messenger; 0/Receptors, Androgen; 50-00-0/Formaldehyde; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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