| Expression analysis of TALE family transcription factors during avian development. | |
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MedLine Citation:
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PMID: 20235232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The TALE family of homeodomain containing transcription factors consists of the Meis, Prep and Tgif, and the Pbx subfamily of proteins. Several TALE orthologues have been identified in amniotes, but no comprehensive analysis of their expression pattern during embryogenesis has been performed. Here, we report on TALE gene expression in the avian embryo. During embryonic development, Pbx genes are predominantly expressed in the neural ectoderm and paraxial mesoderm, although Pbx3 is restricted to the intermediate and lateral mesoderm, and anterior central nervous system. Members of the Meis, Prep, and Tgif subfamilies are expressed at high levels in the paraxial mesoderm, and display differential expression along the anterior-posterior and dorsoventral axes of the developing neural tube. Overall the expression patterns reported in this study are consistent with the known function of the TALE gene family in controlling early patterning of limb, neural tube and paraxial mesoderm tissues during embryogenesis. |
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Authors:
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Sarah E Coy; Anne-Gaëlle Borycki |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 1234-45 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avian Proteins / genetics*, metabolism Basic Helix-Loop-Helix Transcription Factors / genetics*, metabolism Chick Embryo* / metabolism Cloning, Molecular Gene Expression Profiling Gene Expression Regulation, Developmental* Homeodomain Proteins / genetics, metabolism Models, Biological Multigene Family / genetics Phylogeny |
| Chemical | |
Reg. No./Substance:
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0/Avian Proteins; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Homeodomain Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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