Document Detail


Expression of adrenomedullin and its receptor in lungs of rats with hypoxic pulmonary hypertension.
MedLine Citation:
PMID:  12622928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the role of adrenomedullin (AM) in the development of hypoxic pulmonary hypertension (HPH), and to assess the expression of AM and adrenomedullin receptor (AMR) in the lungs of rats with HPH. METHODS: We exposed 10 rats to normobaric hypoxic conditions for 3 weeks to establish rat model of pulmonary hypertension; and 10 other rats were used as normoxic controls. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization. The thickness of pulmonary arterioles was measured by a computerized image analyzer. We used the reverse transcription-polymerase chain reaction (RT-PCR) to assess the change of expression of AM and AMR in lung of HPH rat model. RESULTS: Compared with the control group, hypoxic rats developed remarkable pulmonary hypertension, increment in the thickness of pulmonary arterioles and right ventricular hypertrophy (P < 0.01). Chronic hypoxia elicited a considerable increment in expression of AM and AMR in the lungs of rats, and the ratio of AM/beta-actin and AMR/beta-actin in lungs of rats treated with hypoxia were significantly higher (P < 0.01). CONCLUSIONS: The AM plays an important role in regulating pulmonary vascular tone and can ameliorate the development of hypoxic pulmonary hypertension in rats.
Authors:
Deyun Cheng; Wei Tian; Wenbin Chen; Xinrong Xiao
Related Documents :
3241608 - The effect of early postnatal hypoxia on the regional cerebral utilization of glucose i...
12360358 - Effect of geomagnetic activity on rat resistance to hypoxia.
12391138 - Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats.
1400048 - Ventilatory and metabolic responses to cold and hypoxia in intact and carotid body-dene...
8781288 - Decreased vascular reactivity in metformin-treated fructose-hypertensive rats.
22584848 - Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1806-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Animals
Anoxia / metabolism*,  pathology
Arterioles / pathology
Gene Expression
Hypertension, Pulmonary / metabolism*,  pathology
Hypertrophy, Right Ventricular / etiology
Lung / metabolism*
Male
Peptides / genetics*
Rats
Rats, Wistar
Receptors, Peptide / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Peptides; 0/Receptors, Peptide; 0/adrenomedullin receptor; 148498-78-6/Adrenomedullin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Primary cutaneous CD30-positive anaplastic large cell lymphoma analysis.
Next Document:  Clinical efficacy of albendazole emulsion in treatment of 212 cases of liver cystic hydatidosis.