Document Detail

Expression of adrenomedullin and its receptor in lungs of rats with hypoxic pulmonary hypertension.
MedLine Citation:
PMID:  12622928     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the role of adrenomedullin (AM) in the development of hypoxic pulmonary hypertension (HPH), and to assess the expression of AM and adrenomedullin receptor (AMR) in the lungs of rats with HPH. METHODS: We exposed 10 rats to normobaric hypoxic conditions for 3 weeks to establish rat model of pulmonary hypertension; and 10 other rats were used as normoxic controls. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization. The thickness of pulmonary arterioles was measured by a computerized image analyzer. We used the reverse transcription-polymerase chain reaction (RT-PCR) to assess the change of expression of AM and AMR in lung of HPH rat model. RESULTS: Compared with the control group, hypoxic rats developed remarkable pulmonary hypertension, increment in the thickness of pulmonary arterioles and right ventricular hypertrophy (P < 0.01). Chronic hypoxia elicited a considerable increment in expression of AM and AMR in the lungs of rats, and the ratio of AM/beta-actin and AMR/beta-actin in lungs of rats treated with hypoxia were significantly higher (P < 0.01). CONCLUSIONS: The AM plays an important role in regulating pulmonary vascular tone and can ameliorate the development of hypoxic pulmonary hypertension in rats.
Deyun Cheng; Wei Tian; Wenbin Chen; Xinrong Xiao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1806-8     Citation Subset:  IM    
Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
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MeSH Terms
Anoxia / metabolism*,  pathology
Arterioles / pathology
Gene Expression
Hypertension, Pulmonary / metabolism*,  pathology
Hypertrophy, Right Ventricular / etiology
Lung / metabolism*
Peptides / genetics*
Rats, Wistar
Receptors, Peptide / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Peptides; 0/Receptors, Peptide; 0/adrenomedullin receptor; 148498-78-6/Adrenomedullin

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