| Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. | |
| | |
MedLine Citation:
|
PMID: 18713296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM: Obesity is one of the risk factors for non-alcoholic fatty liver disease (NAFLD) and a common disease that comprises simple steatosis and non-alcoholic steatohepatitis (NASH), and can eventually lead to liver cirrhosis. Adiponectin is an adipocyte-derived protein that has anti-obesity, antidiabetic and anti-inflammatory properties, and is considered to possess a hepatoprotective function. Its role in the development and progression of NAFLD in morbidly obese patients is unknown. In this study, we examined the expression levels of adiponectin and its receptors in liver biopsies of morbidly obese patients and then determined whether there was an association with the disease severity. METHODS: Liver biopsies from 30 morbidly obese patients (18 NASH vs 12 steatosis) were analyzed. The needle core biopsies were subjected to routine histological examination and stained immunohistochemically for adiponectin, adiponectin receptor I (adipoRI) and receptor II (adipoRII). RESULTS: The two groups were comparable with respect to body mass index, age and gender distribution. The expression of adiponectin decreased in liver biopsies with NASH as compared to those with simple steatosis (1.61 +/- 0.70 vs 2.25 +/- 0.75, P = 0.028). Spearman's rank correlation coefficient analysis showed that the staining intensity of adiponectin negatively correlated with the grade of inflammation (r = -0.368, P = 0.045) and stage of fibrosis (r = -0.380, P = 0.038). There was no significant difference in expression of adipoRI and adipoRII between the two groups. CONCLUSION: These findings indicate that decreased liver adiponectin expression may play a role in the development and progression of NAFLD, from simple steatosis to NASH, in morbidly obese patients. |
| | |
Authors:
|
Hong Ma; Victoria Gomez; Liang Lu; Xiangjiu Yang; Xiaoyan Wu; Shu-Yuan Xiao |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2008-08-17 |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: 24 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-02-13 Completed Date: 2009-05-07 Revised Date: 2012-04-09 |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
|
Languages: eng Pagination: 233-7 Citation Subset: IM |
Affiliation:
|
Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China. mah-169@163.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiponectin
/
analysis Adult Biopsy, Needle Disease Progression Down-Regulation Fatty Liver / etiology, metabolism*, pathology Female Hepatitis / etiology, metabolism Humans Immunohistochemistry Liver / chemistry*, pathology Liver Cirrhosis / etiology, metabolism Male Middle Aged Obesity, Morbid / complications, metabolism*, pathology Receptors, Adiponectin / analysis* Retrospective Studies Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/ADIPOQ protein, human; 0/ADIPOR1 protein, human; 0/ADIPOR2 protein, human; 0/Adiponectin; 0/Receptors, Adiponectin |
| Comments/Corrections | |
Comment In:
|
J Gastroenterol Hepatol. 2009 Feb;24(2):173-5
[PMID:
19215327
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleed...
Next Document: Can computed tomography with coronal reconstruction improve the diagnosis of choledocholithiasis?